Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man.
The effect of two analogues of [Met]-enkephalin, [D-Ala2,N-Phe4,Met(0)-ol5]-enkephalin and its guanyl derivative, on plasma concentrations of atrial natriuretic peptide (ANP) and serum aldosterone in six normal subjects was investigated. All subjects were given a 1 litre water load to inhibit vasopr...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1988
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| _version_ | 1797055710591188992 |
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| author | Borges, F Anderson, J Volta, C Perry, L Drury, P Bloom, SR Besser, G Grossman, A |
| author_facet | Borges, F Anderson, J Volta, C Perry, L Drury, P Bloom, SR Besser, G Grossman, A |
| author_sort | Borges, F |
| collection | OXFORD |
| description | The effect of two analogues of [Met]-enkephalin, [D-Ala2,N-Phe4,Met(0)-ol5]-enkephalin and its guanyl derivative, on plasma concentrations of atrial natriuretic peptide (ANP) and serum aldosterone in six normal subjects was investigated. All subjects were given a 1 litre water load to inhibit vasopressin release. Both analogues, when injected i.v. at a dose of 100 micrograms, stimulated release of prolactin and GH and inhibited serum cortisol; there was no significant change in blood pressure, pulse rate or urine output. Neither plasma concentrations of ANP nor serum aldosterone levels changed significantly after injection of either analogue at a low or high dose. Naloxone, given i.v. as an 8 mg bolus, also failed to alter concentrations of either ANP or aldosterone, while it significantly stimulated the release of serum LH and cortisol. It was concluded that under basal conditions opiate receptors are unable to modulate plasma ANP or serum aldosterone concentrations. |
| first_indexed | 2024-03-06T19:13:41Z |
| format | Journal article |
| id | oxford-uuid:17a1abe6-4376-4b9d-9c10-7e28c9930c89 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:13:41Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:17a1abe6-4376-4b9d-9c10-7e28c9930c892022-03-26T10:38:34ZOpioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:17a1abe6-4376-4b9d-9c10-7e28c9930c89EnglishSymplectic Elements at Oxford1988Borges, FAnderson, JVolta, CPerry, LDrury, PBloom, SRBesser, GGrossman, AThe effect of two analogues of [Met]-enkephalin, [D-Ala2,N-Phe4,Met(0)-ol5]-enkephalin and its guanyl derivative, on plasma concentrations of atrial natriuretic peptide (ANP) and serum aldosterone in six normal subjects was investigated. All subjects were given a 1 litre water load to inhibit vasopressin release. Both analogues, when injected i.v. at a dose of 100 micrograms, stimulated release of prolactin and GH and inhibited serum cortisol; there was no significant change in blood pressure, pulse rate or urine output. Neither plasma concentrations of ANP nor serum aldosterone levels changed significantly after injection of either analogue at a low or high dose. Naloxone, given i.v. as an 8 mg bolus, also failed to alter concentrations of either ANP or aldosterone, while it significantly stimulated the release of serum LH and cortisol. It was concluded that under basal conditions opiate receptors are unable to modulate plasma ANP or serum aldosterone concentrations. |
| spellingShingle | Borges, F Anderson, J Volta, C Perry, L Drury, P Bloom, SR Besser, G Grossman, A Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title | Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title_full | Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title_fullStr | Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title_full_unstemmed | Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title_short | Opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man. |
| title_sort | opioid peptides do not modulate atrial natriuretic peptide or aldosterone release under basal conditions in man |
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