EPR quantification of vascular nitric oxide production in genetically modified mouse models.

EPR quantification of vascular nitric oxide production in genetically modified mouse models.

With increasing use of genetically modified mice to study endothelial nitric oxide (NO) biology, methods for reliable quantification of vascular NO production by mouse tissues are crucial. We describe a technique based on electron paramagnetic resonance (EPR) spectroscopy, using colloid iron (II) di...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Khoo, J, Alp, N, Bendall, J, Kawashima, S, Yokoyama, M, Zhang, Y, Casadei, B, Channon, K
Format:	Journal article
Sprog:	English
Udgivet:	2004

Lignende værker

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
af: Khoo, J, et al.
Udgivet: (2005)

Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue.
af: de Bono, J, et al.
Udgivet: (2007)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
af: Adlam, D, et al.
Udgivet: (2007)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
af: Alp, N, et al.
Udgivet: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
af: Alp, N, et al.
Udgivet: (2004)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
af: Cai, S, et al.
Udgivet: (2004)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
af: Khoo, J, et al.
Udgivet: (2004)

Regulation of myocyte function by gch1 overexpression mediated increase in nitric oxide
af: Hijazo, R, et al.
Udgivet: (2012)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
af: Bendall, J, et al.
Udgivet: (2004)

Nitric oxide and vascular disease
af: Shirodaria, C, et al.
Udgivet: (2007)

Molecular mechanisms underlying the myocardial nitric oxide-redox imbalance in human atrial fibrillation
af: Reilly, SN, et al.
Udgivet: (2009)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
af: Cai, S, et al.
Udgivet: (2005)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
af: Alp, N, et al.
Udgivet: (2003)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
af: Channon, K
Udgivet: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
af: Khoo, J, et al.
Udgivet: (2005)

DETECTION OF NITRIC OXIDE REDUCTION DURING ISCHAEMIA-REPERFUSION BY EPR SPECTROSCOPY
af: KADKHODAEE M, et al.
Udgivet: (2001-01-01)

Reduced vascular nitric oxide bioavailability in diabetes increases platelet activation in vivo: Rescue by endothelium-specific restoration of vascular NO production
af: Schafer, A, et al.
Udgivet: (2003)

Genetic variability of MTHFR affects vascular redox and nitric oxide bioavailability in human vessels, by modifying eNOS coupling
af: Antoniades, C, et al.
Udgivet: (2008)

Rapid regulation of platelet activation in vivo by nitric oxide
af: Schafer, A, et al.
Udgivet: (2003)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
af: Bendall, J, et al.
Udgivet: (2004)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
af: Khoo, J, et al.
Udgivet: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
af: Bendall, J, et al.
Udgivet: (2005)

Neuronal nitric oxide synthase and human vascular regulation.
af: Melikian, N, et al.
Udgivet: (2009)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
af: Alp, N, et al.
Udgivet: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
af: Khoo, J, et al.
Udgivet: (2004)

Diabetes reduces vascular tetrahydrobiopterin levels by oxidation: Insights from a GTPCH-transgenic mouse model
af: Alp, N, et al.
Udgivet: (2003)

Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
af: Antoniades, C, et al.
Udgivet: (2008)

Brain damage led to decrease of nitric oxide content in the hippocampus of rats: Investigation by EPR spectroscopy
af: G.G. Yafarova, et al.
Udgivet: (2018-12-01)

Limits in the use of cPTIO as Nitric Oxide scavenger and EPR probe in plant cells and seedlings
af: Stefano eD'Alessandro, et al.
Udgivet: (2013-08-01)

Malfunction of Vascular Control in Lifestyle-Related Diseases: Endothelial Nitric Oxide (NO) Synthase/NO System in Atherosclerosis
af: Seinosuke Kawashima
Udgivet: (2004-01-01)

EPR OF HYDROGEN IN LITHIUM-OXIDE
af: Baker, J, et al.
Udgivet: (1991)

Genetic Variability of Methyl-Tetrahydrofolate-Reductase Modifies eNOS Coupling in Human Arteries and Veins: Effects on Vascular Superoxide Generation and Nitric Oxide Bioavailabllity
af: Antoniades, C, et al.
Udgivet: (2008)

Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
af: Channon, K, et al.
Udgivet: (2000)

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
af: Cai, S, et al.
Udgivet: (2005)

Time-Dependent and Regional Differences in Myocardial Nitric Oxide-Redox State in Atrial Fibrillation
af: Reilly, S, et al.
Udgivet: (2008)

Nitric oxide-superoxide interactions in human blood vessels: implications for vascular peroxynitrite formation
af: Guzik, T, et al.
Udgivet: (2001)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
af: Alp, N, et al.
Udgivet: (2003)

EPR study of paramagnetic centers in mesoporous titanium dioxide prepared by nitric acid oxidation of titanium carbide
af: Evgeni A. Ovodok, et al.
Udgivet: (2017-12-01)

The Ability of the EPR MOUSE to Study Underpaintings
af: Stanley E. Liang, et al.
Udgivet: (2023-07-01)

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
af: Antoniades, C, et al.
Udgivet: (2011)