Quantitative FLAIR MRI in amyotrophic lateral sclerosis
<strong>Rationale and Objectives</strong> T2-weighted MRI hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to FLAIR MRI intensity across a range of ALS...
| Autors principals: | , , , , , |
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| Format: | Journal article |
| Publicat: |
Elsevier
2017
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| _version_ | 1826260963468247040 |
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| author | Fabes, J Matthews, L Filippini, N Talbot, K Jenkinson, M Turner, M |
| author_facet | Fabes, J Matthews, L Filippini, N Talbot, K Jenkinson, M Turner, M |
| author_sort | Fabes, J |
| collection | OXFORD |
| description | <strong>Rationale and Objectives</strong> T2-weighted MRI hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to FLAIR MRI intensity across a range of ALS phenotypes. <strong>Materials & Methods</strong> Thirty three classical ALS patients, 10 with a flail arm presentation, and 6 with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the corticospinal tract (CST) and corpus callosum were made between 21 healthy controls and within patient phenotypic sub-groups, some of who were studied longitudinally. <strong>Results</strong> Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest sub-group classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS Functional Rating Score. <strong>Conclusion</strong> FLAIR MRI encodes quantifiable information of potential diagnostic, stratification and monitoring value. |
| first_indexed | 2024-03-06T19:14:04Z |
| format | Journal article |
| id | oxford-uuid:17bdb15b-f1aa-4f51-8100-ed7aac25a593 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:14:04Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:17bdb15b-f1aa-4f51-8100-ed7aac25a5932022-03-26T10:39:19ZQuantitative FLAIR MRI in amyotrophic lateral sclerosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:17bdb15b-f1aa-4f51-8100-ed7aac25a593Symplectic Elements at OxfordElsevier2017Fabes, JMatthews, LFilippini, NTalbot, KJenkinson, MTurner, M<strong>Rationale and Objectives</strong> T2-weighted MRI hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to FLAIR MRI intensity across a range of ALS phenotypes. <strong>Materials & Methods</strong> Thirty three classical ALS patients, 10 with a flail arm presentation, and 6 with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the corticospinal tract (CST) and corpus callosum were made between 21 healthy controls and within patient phenotypic sub-groups, some of who were studied longitudinally. <strong>Results</strong> Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest sub-group classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS Functional Rating Score. <strong>Conclusion</strong> FLAIR MRI encodes quantifiable information of potential diagnostic, stratification and monitoring value. |
| spellingShingle | Fabes, J Matthews, L Filippini, N Talbot, K Jenkinson, M Turner, M Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title | Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title_full | Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title_fullStr | Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title_full_unstemmed | Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title_short | Quantitative FLAIR MRI in amyotrophic lateral sclerosis |
| title_sort | quantitative flair mri in amyotrophic lateral sclerosis |
| work_keys_str_mv | AT fabesj quantitativeflairmriinamyotrophiclateralsclerosis AT matthewsl quantitativeflairmriinamyotrophiclateralsclerosis AT filippinin quantitativeflairmriinamyotrophiclateralsclerosis AT talbotk quantitativeflairmriinamyotrophiclateralsclerosis AT jenkinsonm quantitativeflairmriinamyotrophiclateralsclerosis AT turnerm quantitativeflairmriinamyotrophiclateralsclerosis |