Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal antibodies (mAbs) against LGI1. We explore their sequences and binding characteristics, plus their pathogenic potential usin...

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Hlavní autoři:	Ramberger, M, Berretta, A, Tan, JMM, Sun, B, Michael, S, Yeo, T, Theorell, J, Bashford-Rogers, R, Paneva, S, O'Dowd, V, Dedi, N, Topia, S, Griffin, R, Ramirez-Franco, J, El Far, O, Baulac, S, Leite, MI, Sen, A, Jeans, A, McMillan, D, Marshall, D, Anthony, D, Lightwood, D, Waters, P, Irani, SR
Médium:	Journal article
Jazyk:	English
Vydáno:	Oxford University Press 2020

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

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