Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients.
Lymph nodes of patients with lymphadenopathy syndrome (LAS) are characterized by two main histological patterns: hyperplastic reactive (H) and regressive (R). In both conditions, the paracortex (PC) is markedly activated with presence of selectively Ia-1+ high endothelial venules. Using a monoclonal...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1826260993392508928 |
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| author | Baroni, C Pezzella, F |
| author_facet | Baroni, C Pezzella, F |
| author_sort | Baroni, C |
| collection | OXFORD |
| description | Lymph nodes of patients with lymphadenopathy syndrome (LAS) are characterized by two main histological patterns: hyperplastic reactive (H) and regressive (R). In both conditions, the paracortex (PC) is markedly activated with presence of selectively Ia-1+ high endothelial venules. Using a monoclonal antibody for p24, the major core protein of HTLV3, we have immunohistochemically determined the distribution of p24+ cells in lymph nodes from 23 LAS patients' HTLV3-ab serologically positive. p24+ cells were demonstrated in 11 cases. Control nodes were negative. p24+ cells included high endothelial cells of PC postcapillary venules, large perivenular cells, large mono- or binucleated cells in PC and in GC, and few lymphocytelike cells. Our preliminary observations indicate that the majority of p24+ cells are high endothelial and accessory cells that may act either as virus reservoir or as antigen-presenting cells to T4 lymphocytes and to GC B cells. In addition, the positivity of high endothelial cells for p24 might help to explain their selective Ia-1+. |
| first_indexed | 2024-03-06T19:14:33Z |
| format | Journal article |
| id | oxford-uuid:17e5a2e7-f0d6-45bf-b03f-a2fed2c0363c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:14:33Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:17e5a2e7-f0d6-45bf-b03f-a2fed2c0363c2022-03-26T10:40:12ZDistribution of p24 HTLV3 major core protein in lymph nodes of LAS patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:17e5a2e7-f0d6-45bf-b03f-a2fed2c0363cEnglishSymplectic Elements at Oxford1987Baroni, CPezzella, FLymph nodes of patients with lymphadenopathy syndrome (LAS) are characterized by two main histological patterns: hyperplastic reactive (H) and regressive (R). In both conditions, the paracortex (PC) is markedly activated with presence of selectively Ia-1+ high endothelial venules. Using a monoclonal antibody for p24, the major core protein of HTLV3, we have immunohistochemically determined the distribution of p24+ cells in lymph nodes from 23 LAS patients' HTLV3-ab serologically positive. p24+ cells were demonstrated in 11 cases. Control nodes were negative. p24+ cells included high endothelial cells of PC postcapillary venules, large perivenular cells, large mono- or binucleated cells in PC and in GC, and few lymphocytelike cells. Our preliminary observations indicate that the majority of p24+ cells are high endothelial and accessory cells that may act either as virus reservoir or as antigen-presenting cells to T4 lymphocytes and to GC B cells. In addition, the positivity of high endothelial cells for p24 might help to explain their selective Ia-1+. |
| spellingShingle | Baroni, C Pezzella, F Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title | Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title_full | Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title_fullStr | Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title_full_unstemmed | Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title_short | Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. |
| title_sort | distribution of p24 htlv3 major core protein in lymph nodes of las patients |
| work_keys_str_mv | AT baronic distributionofp24htlv3majorcoreproteininlymphnodesoflaspatients AT pezzellaf distributionofp24htlv3majorcoreproteininlymphnodesoflaspatients |