Systems biology: an approach.
In just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now pr...
| Glavni autori: | , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2010
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| _version_ | 1826261022948720640 |
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| author | Kohl, P Crampin, E Quinn, T Noble, D |
| author_facet | Kohl, P Crampin, E Quinn, T Noble, D |
| author_sort | Kohl, P |
| collection | OXFORD |
| description | In just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now produces more than 2 million hits. Of the 2,800 entries in PubMed with "Systems Biology" in either the title or the abstract, only two papers were published before 2000, and >90% were published in the past five years. In this article, we interpret Systems Biology as an approach rather than as a field or a destination of research. We illustrate that this approach is productive for the exploration of systems behavior, or "phenotypes," at all levels of structural and functional complexity, explicitly including the supracellular domain, and suggest how this may be related conceptually to genomes and biochemical networks. We discuss the role of models in Systems Biology and conclude with a consideration of their utility in biomedical research and development. |
| first_indexed | 2024-03-06T19:15:00Z |
| format | Journal article |
| id | oxford-uuid:180a554b-275e-409b-a0a2-5b95bcafde3f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:15:00Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:180a554b-275e-409b-a0a2-5b95bcafde3f2022-03-26T10:41:07ZSystems biology: an approach.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:180a554b-275e-409b-a0a2-5b95bcafde3fEnglishSymplectic Elements at Oxford2010Kohl, PCrampin, EQuinn, TNoble, DIn just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now produces more than 2 million hits. Of the 2,800 entries in PubMed with "Systems Biology" in either the title or the abstract, only two papers were published before 2000, and >90% were published in the past five years. In this article, we interpret Systems Biology as an approach rather than as a field or a destination of research. We illustrate that this approach is productive for the exploration of systems behavior, or "phenotypes," at all levels of structural and functional complexity, explicitly including the supracellular domain, and suggest how this may be related conceptually to genomes and biochemical networks. We discuss the role of models in Systems Biology and conclude with a consideration of their utility in biomedical research and development. |
| spellingShingle | Kohl, P Crampin, E Quinn, T Noble, D Systems biology: an approach. |
| title | Systems biology: an approach. |
| title_full | Systems biology: an approach. |
| title_fullStr | Systems biology: an approach. |
| title_full_unstemmed | Systems biology: an approach. |
| title_short | Systems biology: an approach. |
| title_sort | systems biology an approach |
| work_keys_str_mv | AT kohlp systemsbiologyanapproach AT crampine systemsbiologyanapproach AT quinnt systemsbiologyanapproach AT nobled systemsbiologyanapproach |