Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum
Malaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate new druggable targets. Plasmodium falciparum aminoac...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2018
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| _version_ | 1826261073382080512 |
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| author | Manickam, Y Chaturvedi, R Babbar, P Malhotra, N Jain, V Sharma, A |
| author_facet | Manickam, Y Chaturvedi, R Babbar, P Malhotra, N Jain, V Sharma, A |
| author_sort | Manickam, Y |
| collection | OXFORD |
| description | Malaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate new druggable targets. Plasmodium falciparum aminoacyl-tRNA synthetases (Pf-aaRSs) drive protein translation and are potent targets for development of next-generation antimalarials. Here, we detail advances made in structural-biology-based investigations in Pf-aaRSs and discuss their distribution of druggable pockets. This review establishes a platform for systematic experimental dissection of malarial parasite aaRSs as a new focus for sustained drug development efforts against malaria. |
| first_indexed | 2024-03-06T19:15:50Z |
| format | Journal article |
| id | oxford-uuid:1853ec10-9669-4ba1-b224-d914ed01f71f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:15:50Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:1853ec10-9669-4ba1-b224-d914ed01f71f2022-03-26T10:42:42ZDrug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparumJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1853ec10-9669-4ba1-b224-d914ed01f71fEnglishSymplectic Elements at OxfordElsevier2018Manickam, YChaturvedi, RBabbar, PMalhotra, NJain, VSharma, AMalaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate new druggable targets. Plasmodium falciparum aminoacyl-tRNA synthetases (Pf-aaRSs) drive protein translation and are potent targets for development of next-generation antimalarials. Here, we detail advances made in structural-biology-based investigations in Pf-aaRSs and discuss their distribution of druggable pockets. This review establishes a platform for systematic experimental dissection of malarial parasite aaRSs as a new focus for sustained drug development efforts against malaria. |
| spellingShingle | Manickam, Y Chaturvedi, R Babbar, P Malhotra, N Jain, V Sharma, A Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title | Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title_full | Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title_fullStr | Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title_full_unstemmed | Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title_short | Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum |
| title_sort | drug targeting of one or more aminoacyl trna synthetase in the malaria parasite plasmodium falciparum |
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