Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.
We present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T--&g...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2004
|
| _version_ | 1826261097151201280 |
|---|---|
| author | Fitness, J Floyd, S Warndorff, D Sichali, L Mwaungulu, L Crampin, A Fine, P Hill, A |
| author_facet | Fitness, J Floyd, S Warndorff, D Sichali, L Mwaungulu, L Crampin, A Fine, P Hill, A |
| author_sort | Fitness, J |
| collection | OXFORD |
| description | We present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T-->C change in codon 352 of the vitamin D receptor gene appeared to be at high risk (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.6-11.4, P = 0.004), while homozygotes for the McCoy b blood group defining variant K1590E in exon 29 of the complement receptor 1 (formerly CD35) gene appeared to be protected (OR = 0.3, 95% CI = 0.1-0.8, P = 0.02). Borderline evidence for association with leprosy susceptibility was found for seven polymorphic sites in an additional six genes. Some of these apparent associations may be false-positive results from multiple comparisons, and several associations suggested by studies in other populations were not replicated here. These data provide evidence of inter-population heterogeneity in leprosy susceptibility. |
| first_indexed | 2024-03-06T19:16:13Z |
| format | Journal article |
| id | oxford-uuid:187772f2-bda5-4551-b70b-1e9699809ba9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:16:13Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:187772f2-bda5-4551-b70b-1e9699809ba92022-03-26T10:43:25ZLarge-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:187772f2-bda5-4551-b70b-1e9699809ba9EnglishSymplectic Elements at Oxford2004Fitness, JFloyd, SWarndorff, DSichali, LMwaungulu, LCrampin, AFine, PHill, AWe present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T-->C change in codon 352 of the vitamin D receptor gene appeared to be at high risk (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.6-11.4, P = 0.004), while homozygotes for the McCoy b blood group defining variant K1590E in exon 29 of the complement receptor 1 (formerly CD35) gene appeared to be protected (OR = 0.3, 95% CI = 0.1-0.8, P = 0.02). Borderline evidence for association with leprosy susceptibility was found for seven polymorphic sites in an additional six genes. Some of these apparent associations may be false-positive results from multiple comparisons, and several associations suggested by studies in other populations were not replicated here. These data provide evidence of inter-population heterogeneity in leprosy susceptibility. |
| spellingShingle | Fitness, J Floyd, S Warndorff, D Sichali, L Mwaungulu, L Crampin, A Fine, P Hill, A Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title | Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title_full | Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title_fullStr | Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title_full_unstemmed | Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title_short | Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. |
| title_sort | large scale candidate gene study of leprosy susceptibility in the karonga district of northern malawi |
| work_keys_str_mv | AT fitnessj largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT floyds largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT warndorffd largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT sichalil largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT mwaungulul largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT crampina largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT finep largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi AT hilla largescalecandidategenestudyofleprosysusceptibilityinthekarongadistrictofnorthernmalawi |