Quantitative prediction of NF-kappa B DNA-protein interactions.

Quantitative prediction of NF-kappa B DNA-protein interactions.

We describe a general method based on principal coordinates analysis to predict the effects of single-nucleotide polymorphisms within regulatory sequences on DNA-protein interactions. We use binding data for the transcription factor NF-kappaB as a test system. The method incorporates the effects of...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Udalova, I, Mott, R, Field, D, Kwiatkowski, D
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2002

Antzeko izenburuak

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.
nork: Nijnik, A, et al.
Argitaratua: (2003)

Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.
nork: Udalova, I, et al.
Argitaratua: (2001)

Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes.
nork: Udalova, I, et al.
Argitaratua: (1998)

Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein.
nork: Udalova, I, et al.
Argitaratua: (2000)

Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region.
nork: Udalova, I, et al.
Argitaratua: (2002)

Inflammatory bowel disease is associated with functional TNF polymorphism affecting OCT1/NF-kappa B interaction
nork: van Heel, D, et al.
Argitaratua: (2002)

Quantitative profiling of protein-DNA binding on microarrays.
nork: Ragoussis, J, et al.
Argitaratua: (2006)

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.
nork: van Heel, D, et al.
Argitaratua: (2002)

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
nork: Udalova, I, et al.
Argitaratua: (2000)

Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.
nork: Goh, F, et al.
Argitaratua: (2009)

Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages.
nork: Kuprash, D, et al.
Argitaratua: (1995)

Quantitative high-throughput analysis of transcription factor binding specificities.
nork: Linnell, J, et al.
Argitaratua: (2004)

[Two steps in activating human tumor necrosis factor gene transcription in macrophages. The role of proteins from the NF-kappa B/Rel family in the effect of lipopolysaccharide]
nork: Udalova, I, et al.
Argitaratua: (1995)

Two steps in activating human tumor necrosis factor gene transcription in macrophages. The role of proteins from the NF-kappa B/Rel family in the effect of lipopolysaccharide
nork: Udalova, I, et al.
Argitaratua: (1995)

Mechanism of inactivation of NF-kappa B by a viral homologue of I kappa b alpha. Signal-induced release of i kappa b alpha results in binding of the viral homologue to NF-kappa B.
nork: Tait, S, et al.
Argitaratua: (2000)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
nork: Smith, C, et al.
Argitaratua: (2001)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
nork: Andreakos, E, et al.
Argitaratua: (2006)

Visualization of lymphatic vessels through NF-kappaB activity.
nork: Saban, MR, et al.
Argitaratua: (2004)

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
nork: Bruce S Hostager, et al.
Argitaratua: (2010-06-01)

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
nork: Cherukuri Sudhakar, et al.
Argitaratua: (2009-01-01)

The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.
nork: Virginie Ropars, et al.
Argitaratua: (2009-08-01)

Activation of nuclear factor-kappa B (NF-kappa B)in diarrhoea predominant irritable bowel syndrome
nork: O'Sullivan, M, et al.
Argitaratua: (2001)

Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function.
nork: Xiaofei Gao, et al.
Argitaratua: (2009-12-01)

Pankreas duktal adenokarsinomunda NF-Kappa B ekspresyonu
nork: Deniz TUNÇEL, et al.
Argitaratua: (2019-06-01)

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
nork: Brian K Bednarski, et al.
Argitaratua: (2009-09-01)

Accuracy and reproducibility of protein-DNA microarray technology.
nork: Field, S, et al.
Argitaratua: (2007)

Accuracy and reproducibility of protein-DNA microarray technology
nork: Field, S, et al.
Argitaratua: (2006)

Significance of Nuclear Factor-Kappa B (NF-κB) and Survivin in Breast Cancer and Their Association with Radiosensitivity and Prognosis
nork: Cao Q, et al.
Argitaratua: (2023-03-01)

Introducing spatial information into predictive NF-kappaB modelling--an agent-based approach.
nork: Mark Pogson, et al.
Argitaratua: (2008-06-01)

Examining the role of nuclear factor kappa-B proteins in human cytokine gene expression: Comparison of type I and type III interferons
nork: Goh, F, et al.
Argitaratua: (2008)

Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.
nork: Clarke, C, et al.
Argitaratua: (1995)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
nork: Michael Schuliga
Argitaratua: (2015-06-01)

Compartimentalized NF-kappaB activity in the axon initial segment
nork: Prehn Jochen, et al.
Argitaratua: (2007-03-01)

The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
nork: Thomas Karrasch, et al.
Argitaratua: (2007-07-01)

The NFκB Expression on Apical Dental Granuloma: An Immunohistochemistry Analysis
nork: Cilmiaty R, et al.
Argitaratua: (2020-08-01)

Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.
nork: Kartsogiannis, V, et al.
Argitaratua: (1999)

NF-kappaB mediates Gadd45beta expression and DNA demethylation in the hippocampus during fear memory formation.
nork: Timothy J Jarome, et al.
Argitaratua: (2015-09-01)

Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages.
nork: Denys, A, et al.
Argitaratua: (2002)

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
nork: Anna Okvist, et al.
Argitaratua: (2007-09-01)

Activation of NF-kappa B signaling promotes growth of prostate cancer cells in bone
nork: Jin, R, et al.
Argitaratua: (2013)