The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, are not well understood. Here, we review evidence from clinical trials abo...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2021
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| _version_ | 1797109682561613824 |
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| author | Murphy, SE Capitão, LP Giles, SLC Cowen, PJ Stringaris, A Harmer, CJ |
| author_facet | Murphy, SE Capitão, LP Giles, SLC Cowen, PJ Stringaris, A Harmer, CJ |
| author_sort | Murphy, SE |
| collection | OXFORD |
| description | The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, are not well understood. Here, we review evidence from clinical trials about the benefits and risks of SSRIs in young people and consider their mechanisms of action, as shown through human experimental work and animal models. We emphasise key outstanding questions about the effects of SSRIs in youth, identified through gaps in the literature and in consultation with young people with lived experience. It is crucial to characterise the mechanisms underpinning risks and benefits of SSRIs in this age group to progress the field, and to narrow the chasm between the widespread use of SSRIs in youth and the science on which this use is based. |
| first_indexed | 2024-03-07T07:44:57Z |
| format | Journal article |
| id | oxford-uuid:18b3e98e-2159-4eee-8b08-c688b97b53b4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:44:57Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:18b3e98e-2159-4eee-8b08-c688b97b53b42023-05-25T15:41:04ZThe knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of actionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18b3e98e-2159-4eee-8b08-c688b97b53b4EnglishSymplectic ElementsElsevier2021Murphy, SECapitão, LPGiles, SLCCowen, PJStringaris, AHarmer, CJThe use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, are not well understood. Here, we review evidence from clinical trials about the benefits and risks of SSRIs in young people and consider their mechanisms of action, as shown through human experimental work and animal models. We emphasise key outstanding questions about the effects of SSRIs in youth, identified through gaps in the literature and in consultation with young people with lived experience. It is crucial to characterise the mechanisms underpinning risks and benefits of SSRIs in this age group to progress the field, and to narrow the chasm between the widespread use of SSRIs in youth and the science on which this use is based. |
| spellingShingle | Murphy, SE Capitão, LP Giles, SLC Cowen, PJ Stringaris, A Harmer, CJ The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title | The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title_full | The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title_fullStr | The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title_full_unstemmed | The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title_short | The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action |
| title_sort | knowns and unknowns of ssri treatment in young people with depression and anxiety efficacy predictors and mechanisms of action |
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