The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, are not well understood. Here, we review evidence from clinical trials abo...

Descripció completa

Dades bibliogràfiques
Autors principals:	Murphy, SE, Capitão, LP, Giles, SLC, Cowen, PJ, Stringaris, A, Harmer, CJ
Format:	Journal article
Idioma:	English
Publicat:	Elsevier 2021

Ítems similars

'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.
per: Harmer, C, et al.
Publicat: (2013)

'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.
per: Harmer, C, et al.
Publicat: (2013)

SSRI enhances sensitivity to background outcomes and modulates response rates: A randomized double blind study of instrumental action and depression
per: Msetfi, RM, et al.
Publicat: (2016)

Neural response to implicit emotions as biomarkers of clinical response to SSRI treatment in depression
per: Godlewska, B, et al.
Publicat: (2017)

Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
per: Capitão, LP, et al.
Publicat: (2022)

Does tryptophan supplementation induce similar changes in emotional processing to an SSRI?
per: Murphy, SE, et al.
Publicat: (2005)

Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns
per: Taquet, M, et al.
Publicat: (2021)

Short-term SSRI treatment remediates amygdala hyperactivity in depressed patients
per: Godlewska, B, et al.
Publicat: (2011)

Short-term SSRI treatment normalises amygdala hyperactivity in depressed patients.
per: Godlewska, B, et al.
Publicat: (2012)

Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
per: Chen, R, et al.
Publicat: (2020)

Using pharmacological fMRI to examine the effect of an SSRI on the neural circuitry underpinning threat processing
per: Murphy, SE, et al.
Publicat: (2008)

Fronto-limbic effective connectivity as possible predictor of antidepressant response to SSRI administration
per: Vai, B, et al.
Publicat: (2016)

Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression.
per: Bhagwagar, Z, et al.
Publicat: (2004)

Early changes in emotional processing as a marker of clinical response to SSRI treatment in depression
per: Godlewska, B, et al.
Publicat: (2016)

SHORT-TERM SSRI TREATMENT REMEDIATES AMYGDALA HYPERACTIVITY IN DEPRESSED PATIENTS: A PLACEBO-CONTROLLED STUDY
per: Godlewska, B, et al.
Publicat: (2011)

Augmentation of SSRI treatment
per: Cowen, P
Publicat: (2008)

The serotonin 1A (5-HT1A) receptor as a pharmacological target in depression
per: Smith, ALW, et al.
Publicat: (2023)

Using pharmacological fMRI to examine the effect of an SSRI on the neural circuitry underpinning threat processing
per: Murphy, S, et al.
Publicat: (2008)

Mechanisms of enhancer action: the known and the unknown
per: Anil Panigrahi, et al.
Publicat: (2021-04-01)

Acute SSRI administration affects the processing of social cues in healthy volunteers.
per: Harmer, C, et al.
Publicat: (2003)

Olanzapine increases slow wave sleep and sleep continuity in SSRI-resistant depressed patients.
per: Sharpley, A, et al.
Publicat: (2005)

The effect of the 5-HT4 agonist, Prucalopride, on a functional magnetic resonance imaging faces task in the healthy human brain
per: de Cates, AN, et al.
Publicat: (2022)

Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research
per: Colwell, MJ, et al.
Publicat: (2022)

SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex
per: McCabe, C, et al.
Publicat: (2011)

SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex.
per: McCabe, C, et al.
Publicat: (2011)

Differences between SSRI and SNRI in depression treatment
per: Mateusz Grego, et al.
Publicat: (2025-01-01)

Association between a selective 5-HT4 receptor agonist and incidence of major depressive disorder: emulated target trial
per: de Cates, AN, et al.
Publicat: (2024)

The Known Into the Unknown
per: Antonio Sorgente, MD, PhD, et al.
Publicat: (2020-07-01)

The known and the unknown
per: Editorial
Publicat: (2010-01-01)

The known knowns and known unknowns of peacekeeping data
per: Dorussen, H, et al.
Publicat: (2016)

Anxiety increases breakthrough of threat stimuli in continuous flash suppression.
per: Capitão, L, et al.
Publicat: (2014)

Statins in depression: a repurposed medical treatment can provide novel insights in mental health
per: De Giorgi, R, et al.
Publicat: (2022)

Thyroid hormone action in adult neurogliogenic niches: the known and unknown
per: Victor Valcárcel-Hernández, et al.
Publicat: (2024-03-01)

Restless Legs Syndrome: Known Knowns and Known Unknowns
per: Elena Antelmi, et al.
Publicat: (2022-01-01)

Translating the promise of 5HT4 receptor agonists for the treatment of depression
per: Murphy, SE, et al.
Publicat: (2020)

SSRI treatment decreases prolactin and hyperthermic responses to mCPP.
per: Quested, D, et al.
Publicat: (1997)

A translational perspective on the anti-anhedonic effect of ketamine and its neural underpinnings
per: Pulcu, E, et al.
Publicat: (2021)

Cardioneuroablation: the known and the unknown
per: A. Marrese, et al.
Publicat: (2024-07-01)

Vildagliptin: the known and unknown
per: L. Y. Morgunov
Publicat: (2016-12-01)

Anxiety increases breakthrough of threat stimuli in continuous flash suppression
per: Yang, E, et al.
Publicat: (2014)