Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.

Intramembrane proteases have the unusual property of cleaving peptide bonds within the lipid bilayer, an environment not obviously suited to a water-requiring hydrolysis reaction. These enzymes include site-2 protease, gamma-secretase/presenilin, signal peptide peptidase and the rhomboids, and they...

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Príomhchruthaitheoirí: Lemberg, M, Menendez, J, Misik, A, Garcia, M, Koth, C, Freeman, M
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2005