A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro
Two challenges in the management of Acute Respiratory Distress Syndrome are the difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation therapy in real-time. Commercial optical oxygen sensors can detect <em>P</em><sub><em>a</em><s...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2014
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| _version_ | 1797055975800176640 |
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| author | Formenti, F Chen, R McPeak, H Matejovic, M Farmery, A Hahn, C |
| author_facet | Formenti, F Chen, R McPeak, H Matejovic, M Farmery, A Hahn, C |
| author_sort | Formenti, F |
| collection | OXFORD |
| description | Two challenges in the management of Acute Respiratory Distress Syndrome are the difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation therapy in real-time. Commercial optical oxygen sensors can detect <em>P</em><sub><em>a</em><sub>O<sub>2</sub></sub></sub> oscillations associated with cyclical atelectasis, but are not accurate at saturation levels below 90%, and contain a toxic fluorophore. We present a computer-controlled test rig, together with an in-house constructed ultra-rapid sensor to test the limitations of these sensors when exposed to rapidly changing <em>P</em><sub>O<sub>2</sub></sub> in blood <em>in vitro</em>. We tested the sensors' responses to simulated respiratory rates between 10 and 60 breaths per minute. Our sensor was able to detect the whole amplitude of the imposed <em>P</em><sub>O<sub>2</sub></sub> oscillations, even at the highest respiratory rate. We also examined our sensor's resistance to clot formation by continuous <em>in vivo</em> deployment in non-heparinised flowing animal blood for 24 h, after which no adsorption of organic material on the sensor's surface was detectable by scanning electron microscopy. |
| first_indexed | 2024-03-06T19:16:58Z |
| format | Journal article |
| id | oxford-uuid:18bd6f17-df6f-4b6a-806a-1ad4fbc5ee93 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:16:58Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:18bd6f17-df6f-4b6a-806a-1ad4fbc5ee932022-03-26T10:44:50ZA fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitroJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18bd6f17-df6f-4b6a-806a-1ad4fbc5ee93EnglishSymplectic Elements at OxfordElsevier2014Formenti, FChen, RMcPeak, HMatejovic, MFarmery, AHahn, CTwo challenges in the management of Acute Respiratory Distress Syndrome are the difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation therapy in real-time. Commercial optical oxygen sensors can detect <em>P</em><sub><em>a</em><sub>O<sub>2</sub></sub></sub> oscillations associated with cyclical atelectasis, but are not accurate at saturation levels below 90%, and contain a toxic fluorophore. We present a computer-controlled test rig, together with an in-house constructed ultra-rapid sensor to test the limitations of these sensors when exposed to rapidly changing <em>P</em><sub>O<sub>2</sub></sub> in blood <em>in vitro</em>. We tested the sensors' responses to simulated respiratory rates between 10 and 60 breaths per minute. Our sensor was able to detect the whole amplitude of the imposed <em>P</em><sub>O<sub>2</sub></sub> oscillations, even at the highest respiratory rate. We also examined our sensor's resistance to clot formation by continuous <em>in vivo</em> deployment in non-heparinised flowing animal blood for 24 h, after which no adsorption of organic material on the sensor's surface was detectable by scanning electron microscopy. |
| spellingShingle | Formenti, F Chen, R McPeak, H Matejovic, M Farmery, A Hahn, C A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title | A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title_full | A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title_fullStr | A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title_full_unstemmed | A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title_short | A fibre optic oxygen sensor that detects rapid PO₂ changes under simulated conditions of cyclical atelectasis in vitro |
| title_sort | fibre optic oxygen sensor that detects rapid po₂ changes under simulated conditions of cyclical atelectasis in vitro |
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