SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE
A short synthesis of epinoroxetanocin [9-(β-D-threo-oxetanosyl)adenine], free from its α-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A comparison of the in vitro activity against HIV-1 of oxetanocin, no...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1990
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| _version_ | 1826261159308689408 |
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| author | Wang, Y Fleet, G Storer, R Myers, P Wallis, C Doherty, O Watkin, D Vogt, K Witty, D Wilson, F Peach, J |
| author_facet | Wang, Y Fleet, G Storer, R Myers, P Wallis, C Doherty, O Watkin, D Vogt, K Witty, D Wilson, F Peach, J |
| author_sort | Wang, Y |
| collection | OXFORD |
| description | A short synthesis of epinoroxetanocin [9-(β-D-threo-oxetanosyl)adenine], free from its α-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A comparison of the in vitro activity against HIV-1 of oxetanocin, noroxetanocin and epinoroxetanocin as anti-viral agents is given. © 1990. |
| first_indexed | 2024-03-06T19:17:09Z |
| format | Journal article |
| id | oxford-uuid:18cbef90-abf2-48f3-982e-23d6f43081a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:17:09Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:18cbef90-abf2-48f3-982e-23d6f43081a62022-03-26T10:45:11ZSYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONEJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18cbef90-abf2-48f3-982e-23d6f43081a6EnglishSymplectic Elements at Oxford1990Wang, YFleet, GStorer, RMyers, PWallis, CDoherty, OWatkin, DVogt, KWitty, DWilson, FPeach, JA short synthesis of epinoroxetanocin [9-(β-D-threo-oxetanosyl)adenine], free from its α-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A comparison of the in vitro activity against HIV-1 of oxetanocin, noroxetanocin and epinoroxetanocin as anti-viral agents is given. © 1990. |
| spellingShingle | Wang, Y Fleet, G Storer, R Myers, P Wallis, C Doherty, O Watkin, D Vogt, K Witty, D Wilson, F Peach, J SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title | SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title_full | SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title_fullStr | SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title_full_unstemmed | SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title_short | SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE |
| title_sort | synthesis of the potent antiviral oxetane nucleoside epinoroxetanocin from d lyxonolactone |
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