Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines?
<h4>Background</h4> <p>Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain...
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Oxford University Press
2018
|
| _version_ | 1826261163380310016 |
|---|---|
| author | Toor, J Alsallaq, R Truscott, J Turner, H Werkman, M Gurarie, D King, C Anderson, R |
| author_facet | Toor, J Alsallaq, R Truscott, J Turner, H Werkman, M Gurarie, D King, C Anderson, R |
| author_sort | Toor, J |
| collection | OXFORD |
| description | <h4>Background</h4> <p>Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. These models can inform and guide implementation policy for mass drug administration programs, and help design monitoring and evaluation activities.</p> <h4>Methods</h4> <p>We use these models to predict whether the guidelines set by the WHO are on track for achieving their 2020 goal for the control of morbidity, specifically for Schistosoma mansoni. We examine whether programmatic adaptations; namely increases in treatment coverage and/or expansion to adult inclusion in treatment, will improve the likelihood of reaching the WHO goals.</p> <h4>Results</h4> <p>We find that in low-prevalence settings, the goals are likely to be attainable under current WHO guidelines, but in moderate to high-prevalence settings, the goals are less likely to be achieved unless treatment coverage is increased and expanded to at least 85% for school-aged children and 40% for adults.</p> <h4>Conclusions</h4> <p>To improve the likelihood of reaching the WHO goals, programmatic adaptations are required, particularly for moderate- to high-prevalence settings. Furthermore, improvements in adherence to treatment, potential development of candidate vaccines, and enhanced snail control and WASH (water, sanitation, and hygiene) measures will all assist in achieving the goals.</p> |
| first_indexed | 2024-03-06T19:17:13Z |
| format | Journal article |
| id | oxford-uuid:18d0e923-3fc5-4e46-b8e6-718c23e16e0f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:17:13Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:18d0e923-3fc5-4e46-b8e6-718c23e16e0f2022-03-26T10:45:23ZAre we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18d0e923-3fc5-4e46-b8e6-718c23e16e0fEnglishSymplectic Elements at OxfordOxford University Press2018Toor, JAlsallaq, RTruscott, JTurner, HWerkman, MGurarie, DKing, CAnderson, R <h4>Background</h4> <p>Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. These models can inform and guide implementation policy for mass drug administration programs, and help design monitoring and evaluation activities.</p> <h4>Methods</h4> <p>We use these models to predict whether the guidelines set by the WHO are on track for achieving their 2020 goal for the control of morbidity, specifically for Schistosoma mansoni. We examine whether programmatic adaptations; namely increases in treatment coverage and/or expansion to adult inclusion in treatment, will improve the likelihood of reaching the WHO goals.</p> <h4>Results</h4> <p>We find that in low-prevalence settings, the goals are likely to be attainable under current WHO guidelines, but in moderate to high-prevalence settings, the goals are less likely to be achieved unless treatment coverage is increased and expanded to at least 85% for school-aged children and 40% for adults.</p> <h4>Conclusions</h4> <p>To improve the likelihood of reaching the WHO goals, programmatic adaptations are required, particularly for moderate- to high-prevalence settings. Furthermore, improvements in adherence to treatment, potential development of candidate vaccines, and enhanced snail control and WASH (water, sanitation, and hygiene) measures will all assist in achieving the goals.</p> |
| spellingShingle | Toor, J Alsallaq, R Truscott, J Turner, H Werkman, M Gurarie, D King, C Anderson, R Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title | Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title_full | Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title_fullStr | Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title_full_unstemmed | Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title_short | Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines? |
| title_sort | are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current world health organization guidelines |
| work_keys_str_mv | AT toorj areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT alsallaqr areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT truscottj areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT turnerh areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT werkmanm areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT guraried areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT kingc areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines AT andersonr areweonourwaytoachievingthe2020goalsforschistosomiasismorbiditycontrolusingcurrentworldhealthorganizationguidelines |