Sonoluminescence from microbubbles at 1 MHz
This folder contains the raw .tdms and .mat files for the photomultiplier tube and passive cavitation data respectively. This data can be loaded onto MATLAB for analysis of sonoluminescence event counts and frequency analysis of the cavitation data. In this study, we demonstrated that sonoluminescen...
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| Médium: | Dataset |
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University of Oxford
2019
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| Témata: |
| _version_ | 1826261170619678720 |
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| author | Beguin, E |
| author_facet | Beguin, E |
| author_sort | Beguin, E |
| collection | OXFORD |
| description | This folder contains the raw .tdms and .mat files for the photomultiplier tube and passive cavitation data respectively. This data can be loaded onto MATLAB for analysis of sonoluminescence event counts and frequency analysis of the cavitation data. In this study, we demonstrated that sonoluminescence is produced under medically relevant exposure conditions by microbubbles commonly used as contrast agents for ultrasound imaging. This provides a mechanistic explanation for the somewhat controversial reports of “sonodynamic” therapy, in which light-sensitive drugs have been shown to be activated by ultrasound-induced cavitation. To illustrate this, we demonstrated the activation of a photodynamic therapy agent using microbubbles and ultrasound. Since ultrasound can be accurately focused at large tissue depths, this opens up the potential for generating light at locations that cannot be reached by external sources. This could be exploited both for diagnostic and therapeutic applications, significantly increasing the range of applications that are currently restricted by the limited penetration of light in the tissue. |
| first_indexed | 2024-03-06T19:17:20Z |
| format | Dataset |
| id | oxford-uuid:18dc1ccb-2594-4386-b139-2981d7fa5346 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:17:20Z |
| publishDate | 2019 |
| publisher | University of Oxford |
| record_format | dspace |
| spelling | oxford-uuid:18dc1ccb-2594-4386-b139-2981d7fa53462022-03-26T10:45:31ZSonoluminescence from microbubbles at 1 MHzDatasethttp://purl.org/coar/resource_type/c_ddb1uuid:18dc1ccb-2594-4386-b139-2981d7fa5346Sonodynamic TherapySonoluminescenceORA DepositUniversity of Oxford2019Beguin, EThis folder contains the raw .tdms and .mat files for the photomultiplier tube and passive cavitation data respectively. This data can be loaded onto MATLAB for analysis of sonoluminescence event counts and frequency analysis of the cavitation data. In this study, we demonstrated that sonoluminescence is produced under medically relevant exposure conditions by microbubbles commonly used as contrast agents for ultrasound imaging. This provides a mechanistic explanation for the somewhat controversial reports of “sonodynamic” therapy, in which light-sensitive drugs have been shown to be activated by ultrasound-induced cavitation. To illustrate this, we demonstrated the activation of a photodynamic therapy agent using microbubbles and ultrasound. Since ultrasound can be accurately focused at large tissue depths, this opens up the potential for generating light at locations that cannot be reached by external sources. This could be exploited both for diagnostic and therapeutic applications, significantly increasing the range of applications that are currently restricted by the limited penetration of light in the tissue. |
| spellingShingle | Sonodynamic Therapy Sonoluminescence Beguin, E Sonoluminescence from microbubbles at 1 MHz |
| title | Sonoluminescence from microbubbles at 1 MHz |
| title_full | Sonoluminescence from microbubbles at 1 MHz |
| title_fullStr | Sonoluminescence from microbubbles at 1 MHz |
| title_full_unstemmed | Sonoluminescence from microbubbles at 1 MHz |
| title_short | Sonoluminescence from microbubbles at 1 MHz |
| title_sort | sonoluminescence from microbubbles at 1 mhz |
| topic | Sonodynamic Therapy Sonoluminescence |
| work_keys_str_mv | AT beguine sonoluminescencefrommicrobubblesat1mhz |