Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response.
Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of sin...
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2001
|
| _version_ | 1826261175570006016 |
|---|---|
| author | Jenner, T Fulford, J O'Neill, P |
| author_facet | Jenner, T Fulford, J O'Neill, P |
| author_sort | Jenner, T |
| collection | OXFORD |
| description | Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a combination of DNA base lesions and single-strand breaks in proximity. This mini-review discusses some of the recent experimental data confirming the induction of non-DSB, clustered DNA damage by radiation. |
| first_indexed | 2024-03-06T19:17:24Z |
| format | Journal article |
| id | oxford-uuid:18e04ff9-262b-42b5-8f96-1be59e289058 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:17:24Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:18e04ff9-262b-42b5-8f96-1be59e2890582022-03-26T10:45:39ZContribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18e04ff9-262b-42b5-8f96-1be59e289058EnglishSymplectic Elements at Oxford2001Jenner, TFulford, JO'Neill, PBiophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a combination of DNA base lesions and single-strand breaks in proximity. This mini-review discusses some of the recent experimental data confirming the induction of non-DSB, clustered DNA damage by radiation. |
| spellingShingle | Jenner, T Fulford, J O'Neill, P Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title | Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title_full | Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title_fullStr | Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title_full_unstemmed | Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title_short | Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. |
| title_sort | contribution of base lesions to radiation induced clustered dna damage implication for models of radiation response |
| work_keys_str_mv | AT jennert contributionofbaselesionstoradiationinducedclustereddnadamageimplicationformodelsofradiationresponse AT fulfordj contributionofbaselesionstoradiationinducedclustereddnadamageimplicationformodelsofradiationresponse AT oneillp contributionofbaselesionstoradiationinducedclustereddnadamageimplicationformodelsofradiationresponse |