The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure

The McKee-Farrar (MF) prosthesis was the first widely used total hip replacement (THR) to employ a metal-on-metal (MoM) articulation. These implants had a high rate of early aseptic loosening but a number achieved good long-term implant survival, stimulating the reintroduction of second and third ge...

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Autors principals: Munemoto, M, Grammatopoulos, G, Tanaka, Y, Gibbons, M, Athanasou, N
Format: Journal article
Idioma:English
Publicat: Springer 2017
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author Munemoto, M
Grammatopoulos, G
Tanaka, Y
Gibbons, M
Athanasou, N
author_facet Munemoto, M
Grammatopoulos, G
Tanaka, Y
Gibbons, M
Athanasou, N
author_sort Munemoto, M
collection OXFORD
description The McKee-Farrar (MF) prosthesis was the first widely used total hip replacement (THR) to employ a metal-on-metal (MoM) articulation. These implants had a high rate of early aseptic loosening but a number achieved good long-term implant survival, stimulating the reintroduction of second and third generation implants of this type. In this study we analysed archival histopathology of periprosthetic tissues in twenty cases of MF aseptic implant failure to determine if there was evidence of an innate and adaptive immune response similar to that seen in modern MoM implants. The presence of macrophages, the extent of necrosis and the ALVAL response were graded semi-quantitatively. Variable but in most cases extensive tissue necrosis was associated with a heavy macrophage response to Cobalt-Chrome (Co-Cr) wear particles in periprosthetic tissues; most cases also contained evidence of a predominantly lymphocyte response which in eight cases was moderate or heavy (Oxford Grade 2/3). Our findings show that inflammatory and necrotic changes to deposition of Co-Cr wear particles are found in periprosthetic tissues of failed MF implants, indicating that there is an innate and adaptive response similar to that noted in second/third generation MoM implants; they also suggest that the pathobiological response to metal wear particles is likely to have contributed to MF implant failure in these cases.
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spelling oxford-uuid:18f13f9c-cb82-4127-8b7d-903722433c962022-03-26T10:46:11ZThe pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failureJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18f13f9c-cb82-4127-8b7d-903722433c96EnglishSymplectic Elements at OxfordSpringer2017Munemoto, MGrammatopoulos, GTanaka, YGibbons, MAthanasou, NThe McKee-Farrar (MF) prosthesis was the first widely used total hip replacement (THR) to employ a metal-on-metal (MoM) articulation. These implants had a high rate of early aseptic loosening but a number achieved good long-term implant survival, stimulating the reintroduction of second and third generation implants of this type. In this study we analysed archival histopathology of periprosthetic tissues in twenty cases of MF aseptic implant failure to determine if there was evidence of an innate and adaptive immune response similar to that seen in modern MoM implants. The presence of macrophages, the extent of necrosis and the ALVAL response were graded semi-quantitatively. Variable but in most cases extensive tissue necrosis was associated with a heavy macrophage response to Cobalt-Chrome (Co-Cr) wear particles in periprosthetic tissues; most cases also contained evidence of a predominantly lymphocyte response which in eight cases was moderate or heavy (Oxford Grade 2/3). Our findings show that inflammatory and necrotic changes to deposition of Co-Cr wear particles are found in periprosthetic tissues of failed MF implants, indicating that there is an innate and adaptive response similar to that noted in second/third generation MoM implants; they also suggest that the pathobiological response to metal wear particles is likely to have contributed to MF implant failure in these cases.
spellingShingle Munemoto, M
Grammatopoulos, G
Tanaka, Y
Gibbons, M
Athanasou, N
The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title_full The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title_fullStr The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title_full_unstemmed The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title_short The pathology of failed McKee-Farrar implants: correlation with modern metal-on-metal-implant failure
title_sort pathology of failed mckee farrar implants correlation with modern metal on metal implant failure
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