Identification and function of long non-coding RNAs.
It is now clear that eukaryotic cells produce many thousands of non-coding RNAs. The least well-studied of these are longer than 200 nt and are known as lncRNAs (long non-coding RNAs). These loci are of particular interest as their biological relevance remains uncertain. Sequencing projects have ide...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1797056038527041536 |
|---|---|
| author | Young, R Ponting, C |
| author_facet | Young, R Ponting, C |
| author_sort | Young, R |
| collection | OXFORD |
| description | It is now clear that eukaryotic cells produce many thousands of non-coding RNAs. The least well-studied of these are longer than 200 nt and are known as lncRNAs (long non-coding RNAs). These loci are of particular interest as their biological relevance remains uncertain. Sequencing projects have identified thousands of these loci in a variety of species, from flies to humans. Genome-wide scans for functionality, such as evolutionary and expression analyses, suggest that many of these molecules have functional roles to play in the cell. Nevertheless, only a handful of lncRNAs have been experimentally investigated, and most of these appear to possess roles in regulating gene expression at a variety of different levels. Several lncRNAs have also been implicated in cancer. This evidence suggests that lncRNAs represent a new class of non-coding gene whose importance should become clearer upon further experimental investigation. |
| first_indexed | 2024-03-06T19:17:42Z |
| format | Journal article |
| id | oxford-uuid:18f99eac-fe7d-4b80-a31b-e6aa2497524b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:17:42Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:18f99eac-fe7d-4b80-a31b-e6aa2497524b2022-03-26T10:46:17ZIdentification and function of long non-coding RNAs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:18f99eac-fe7d-4b80-a31b-e6aa2497524bEnglishSymplectic Elements at Oxford2013Young, RPonting, CIt is now clear that eukaryotic cells produce many thousands of non-coding RNAs. The least well-studied of these are longer than 200 nt and are known as lncRNAs (long non-coding RNAs). These loci are of particular interest as their biological relevance remains uncertain. Sequencing projects have identified thousands of these loci in a variety of species, from flies to humans. Genome-wide scans for functionality, such as evolutionary and expression analyses, suggest that many of these molecules have functional roles to play in the cell. Nevertheless, only a handful of lncRNAs have been experimentally investigated, and most of these appear to possess roles in regulating gene expression at a variety of different levels. Several lncRNAs have also been implicated in cancer. This evidence suggests that lncRNAs represent a new class of non-coding gene whose importance should become clearer upon further experimental investigation. |
| spellingShingle | Young, R Ponting, C Identification and function of long non-coding RNAs. |
| title | Identification and function of long non-coding RNAs. |
| title_full | Identification and function of long non-coding RNAs. |
| title_fullStr | Identification and function of long non-coding RNAs. |
| title_full_unstemmed | Identification and function of long non-coding RNAs. |
| title_short | Identification and function of long non-coding RNAs. |
| title_sort | identification and function of long non coding rnas |
| work_keys_str_mv | AT youngr identificationandfunctionoflongnoncodingrnas AT pontingc identificationandfunctionoflongnoncodingrnas |