Genomic responses of mouse synovial fibroblasts during tumor necrosis factor-driven arthritogenesis greatly mimic those in human rheumatoid arthritis

<h4>Objective</h4> <p>Aberrant activation of synovial fibroblasts (SFs) is a key determinant in the pathogenesis of rheumatoid arthritis (RA). We aimed to produce a map of gene expression and epigenetic changes occurring in this cell type during disease progression in the human TN...

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Detalhes bibliográficos
Main Authors: Ntougkos, E, Chouvardas, P, Roumelioti, F, Ospelt, C, Frank-Bertoncelj, M, Filer, A, Buckley, C, Gay, S, Nikolaou, C, Kollias, G
Formato: Journal article
Idioma:English
Publicado em: Wiley 2017