The nature of molecular recognition by T cells.
Considerable progress has been made in characterizing four key sets of interactions controlling antigen responsiveness in T cells, involving the following: the T cell antigen receptor, its coreceptors CD4 and CD8, the costimulatory receptors CD28 and CTLA-4, and the accessory molecule CD2. Complemen...
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2003
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| _version_ | 1826261208219516928 |
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| author | Davis, S Ikemizu, S Evans, E Fugger, L Bakker, T Van Der Merwe, P |
| author_facet | Davis, S Ikemizu, S Evans, E Fugger, L Bakker, T Van Der Merwe, P |
| author_sort | Davis, S |
| collection | OXFORD |
| description | Considerable progress has been made in characterizing four key sets of interactions controlling antigen responsiveness in T cells, involving the following: the T cell antigen receptor, its coreceptors CD4 and CD8, the costimulatory receptors CD28 and CTLA-4, and the accessory molecule CD2. Complementary work has defined the general biophysical properties of interactions between cell surface molecules. Among the major conclusions are that these interactions are structurally heterogeneous, often reflecting clear-cut functional constraints, and that, although they all interact relatively weakly, hierarchical differences in the stabilities of the signaling complexes formed by these molecules may influence the sequence of steps leading to T cell activation. Here we review these developments and highlight the major challenges remaining as the field moves toward formulating quantitative models of T cell recognition. |
| first_indexed | 2024-03-06T19:17:54Z |
| format | Journal article |
| id | oxford-uuid:190b5c8a-451d-4c0b-bc6b-06896240b203 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:17:54Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:190b5c8a-451d-4c0b-bc6b-06896240b2032022-03-26T10:46:44ZThe nature of molecular recognition by T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:190b5c8a-451d-4c0b-bc6b-06896240b203EnglishSymplectic Elements at Oxford2003Davis, SIkemizu, SEvans, EFugger, LBakker, TVan Der Merwe, PConsiderable progress has been made in characterizing four key sets of interactions controlling antigen responsiveness in T cells, involving the following: the T cell antigen receptor, its coreceptors CD4 and CD8, the costimulatory receptors CD28 and CTLA-4, and the accessory molecule CD2. Complementary work has defined the general biophysical properties of interactions between cell surface molecules. Among the major conclusions are that these interactions are structurally heterogeneous, often reflecting clear-cut functional constraints, and that, although they all interact relatively weakly, hierarchical differences in the stabilities of the signaling complexes formed by these molecules may influence the sequence of steps leading to T cell activation. Here we review these developments and highlight the major challenges remaining as the field moves toward formulating quantitative models of T cell recognition. |
| spellingShingle | Davis, S Ikemizu, S Evans, E Fugger, L Bakker, T Van Der Merwe, P The nature of molecular recognition by T cells. |
| title | The nature of molecular recognition by T cells. |
| title_full | The nature of molecular recognition by T cells. |
| title_fullStr | The nature of molecular recognition by T cells. |
| title_full_unstemmed | The nature of molecular recognition by T cells. |
| title_short | The nature of molecular recognition by T cells. |
| title_sort | nature of molecular recognition by t cells |
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