Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?
There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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BMJ Publishing Group
1992
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| _version_ | 1826261240557600768 |
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| author | Pile, K Wordsworth, B Bell, J |
| author_facet | Pile, K Wordsworth, B Bell, J |
| author_sort | Pile, K |
| collection | OXFORD |
| description | There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is therefore possible that this locus may also affect the development of RA. Genotype frequencies at this locus, defined by a dimorphic Fok 1 restriction site, were compared in 139 healthy controls and 213 patients with classical/definite RA. In contrast with diabetes there was no increase in genotypes lacking the Fok 1 site, either in the rheumatoid group overall (125/211 compared with 86/139 controls) or in the DR4 positive rheumatoid group (76/140 compared with controls). These results indicate that the interaction between DR4 and a locus on chromosome 11p is not common to all DR4 associated autoimmune diseases. |
| first_indexed | 2024-03-06T19:18:24Z |
| format | Journal article |
| id | oxford-uuid:193752ba-9a15-4118-8201-033726462b5f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:18:24Z |
| publishDate | 1992 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:193752ba-9a15-4118-8201-033726462b5f2022-03-26T10:47:45ZDoes the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:193752ba-9a15-4118-8201-033726462b5fEnglishSymplectic Elements at OxfordBMJ Publishing Group1992Pile, KWordsworth, BBell, JThere is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is therefore possible that this locus may also affect the development of RA. Genotype frequencies at this locus, defined by a dimorphic Fok 1 restriction site, were compared in 139 healthy controls and 213 patients with classical/definite RA. In contrast with diabetes there was no increase in genotypes lacking the Fok 1 site, either in the rheumatoid group overall (125/211 compared with 86/139 controls) or in the DR4 positive rheumatoid group (76/140 compared with controls). These results indicate that the interaction between DR4 and a locus on chromosome 11p is not common to all DR4 associated autoimmune diseases. |
| spellingShingle | Pile, K Wordsworth, B Bell, J Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title | Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title_full | Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title_fullStr | Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title_full_unstemmed | Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title_short | Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis? |
| title_sort | does the locus on chromosome 11 implicated in susceptibility to hla dr4 dependent type i diabetes mellitus also affect susceptibility to rheumatoid arthritis |
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