Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

The Tol system is a five-protein assembly parasitized by colicins and bacteriophages that helps stabilize the Gram-negative outer membrane (OM). We show that allosteric signalling through the six-bladed beta-propeller protein TolB is central to Tol function in Escherichia coli and that this is subve...

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Bibliographic Details
Main Authors: Bonsor, D, Hecht, O, Vankemmelbeke, M, Sharma, A, Krachler, A, Housden, N, Lilly, K, James, R, Moore, G, Kleanthous, K
Format: Journal article
Language:English
Published: 2009