Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

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The advent of anti-TNF biologicals has been a seminal advance in the treatment of rheumatoid arthritis (RA) and has confirmed the important role of TNF in disease pathogenesis. However, it is unknown what sustains the chronic production of TNF. In this study, we have investigated the anti-inflammato...

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Bibliographic Details
Main Authors:	Sacre, S, Lo, A, Gregory, B, Simmonds, R, Williams, L, Feldmann, M, Brennan, F, Foxwell, B
Format:	Journal article
Language:	English
Published:	2008

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