Thoracic involvement in IgG4-related disease in a UK-based patient cohort
IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of t...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
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Elsevier
2017
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| _version_ | 1797056118368763904 |
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| author | Corcoran, J Culver, E Anstey, R Talwar, A Manganis, C Cargill, T Hallifax, R Psallidas, I Rahman, N Barnes, E |
| author_facet | Corcoran, J Culver, E Anstey, R Talwar, A Manganis, C Cargill, T Hallifax, R Psallidas, I Rahman, N Barnes, E |
| author_sort | Corcoran, J |
| collection | OXFORD |
| description | IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of this study was to outline the frequency and nature of thoracic involvement in a prospective cohort of IgG4-RD patients who met defined diagnostic criteria. Over 40% of IgG4-RD patients had clinicoradiological and/or histological evidence of thoracic involvement, predominantly mediastinal lymphadenopathy, the majority associated with multi-system disease outside the chest. Thoracic involvement was associated with a higher serum IgG4 level, potentially representing greater disease activity or spread. Our data highlight the diverse nature of thoracic IgG4-RD, and the importance of knowledge and recognition of the condition among respiratory physicians who are likely to encounter this disease entity on an increasing basis. |
| first_indexed | 2024-03-06T19:18:52Z |
| format | Journal article |
| id | oxford-uuid:195ccaf8-47fb-4a54-b329-8b517f449d75 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:18:52Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:195ccaf8-47fb-4a54-b329-8b517f449d752022-03-26T10:48:38ZThoracic involvement in IgG4-related disease in a UK-based patient cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:195ccaf8-47fb-4a54-b329-8b517f449d75Symplectic Elements at OxfordElsevier2017Corcoran, JCulver, EAnstey, RTalwar, AManganis, CCargill, THallifax, RPsallidas, IRahman, NBarnes, EIgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of this study was to outline the frequency and nature of thoracic involvement in a prospective cohort of IgG4-RD patients who met defined diagnostic criteria. Over 40% of IgG4-RD patients had clinicoradiological and/or histological evidence of thoracic involvement, predominantly mediastinal lymphadenopathy, the majority associated with multi-system disease outside the chest. Thoracic involvement was associated with a higher serum IgG4 level, potentially representing greater disease activity or spread. Our data highlight the diverse nature of thoracic IgG4-RD, and the importance of knowledge and recognition of the condition among respiratory physicians who are likely to encounter this disease entity on an increasing basis. |
| spellingShingle | Corcoran, J Culver, E Anstey, R Talwar, A Manganis, C Cargill, T Hallifax, R Psallidas, I Rahman, N Barnes, E Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title | Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title_full | Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title_fullStr | Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title_full_unstemmed | Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title_short | Thoracic involvement in IgG4-related disease in a UK-based patient cohort |
| title_sort | thoracic involvement in igg4 related disease in a uk based patient cohort |
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