Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.
Dehydroquinate synthase (DHQS) is the N-terminal domain of the pentafunctional AROM protein that catalyses steps 2 to 7 in the shikimate pathway in microbial eukaryotes. DHQS converts 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) to dehydroquinate in a reaction that includes alcohol oxidation,...
Main Authors: | Park, A, Lamb, H, Nichols, C, Moore, J, Brown, K, Cooper, A, Charles, I, Stammers, D, Hawkins, A |
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Format: | Journal article |
Language: | English |
Published: |
2004
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