USP21 prevents the generation of T-helper-1-like Treg cells

USP21 prevents the generation of T-helper-1-like Treg cells

FOXP3+ Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report that the E3 deubiquitinase USP21 prevents the depl...

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Hlavní autoři: Li, Y, Lu, Y, Wang, S, Han, Z, Zhu, F, Ni, Y, Liang, R, Zhang, Y, Leng, Q, Wei, G, Shi, G, Zhu, R, Li, D, Wang, H, Zheng, SG, Xu, H, Tsun, A, Li, B
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2016

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