On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Histone lysine methyltransferases (HKMTs) are an important class of targets for epigenetic therapy. 1 (chaetocin), an epidithiodiketopiperazine (ETP) natural product, has been reported to be a specific inhibitor of the SU(VAR)3-9 class of HKMTs. We have studied the inhibition of the HKMT G9a by 1 an...

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Những tác giả chính:	Cherblanc, F, Chapman, K, Reid, J, Borg, A, Sundriyal, S, Alcazar-Fuoli, L, Bignell, E, Demetriades, M, Schofield, C, DiMaggio, P, Brown, R, Fuchter, M
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2013

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