Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Mouse models for genetic diseases are among the most powerful tools available for developing and testing new treatment strategies. ADAM12 is a disintegrin and metalloprotease, previously demonstrated to significantly alleviate the pathology of mdx mice, a model for Duchenne muscular dystrophy in hum...
Egile Nagusiak: | Moghadaszadeh, B, Albrechtsen, R, Guo, LT, Zaik, M, Kawaguchi, N, Borup, R, Kronqvist, P, Schroder, H, Davies, K, Voit, T, Nielsen, F, Engvall, E, Wewer, U |
---|---|
Formatua: | Journal article |
Hizkuntza: | English |
Argitaratua: |
2003
|
Antzeko izenburuak
-
Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis
nork: Hung-Chih Chen, et al.
Argitaratua: (2017-08-01) -
The utrophin and dystrophin genes share similarities in genomic structure.
nork: Pearce, M, et al.
Argitaratua: (1993) -
Functional substitution by TAT-utrophin in dystrophin-deficient mice.
nork: Kevin J Sonnemann, et al.
Argitaratua: (2009-05-01) -
Immunogold confirmation that utrophin is localized to the normal position of dystrophin in dystrophin-negative transgenic mouse muscle.
nork: Culle, M, et al.
Argitaratua: (2001) -
The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy
nork: Guiraud, S, et al.
Argitaratua: (2019)