Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders.
<h4>Objective</h4> <p>Erythropoietin (EPO) improves verbal memory and reverses sub-field hippocampal volume loss across depression and bipolar disorder. This study aimed to investigate with functional magnetic resonance imaging (fMRI) whether these effects were accompanied by func...
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Wiley
2016
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| _version_ | 1826261371509014528 |
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| author | Miskowiak, K Macoveanu, J Vinberg, M Assentoft, E Randers, L Harmer, C Ehrenreich, H Paulson, O Knudsen, G Siebner, H Kessing, L |
| author_facet | Miskowiak, K Macoveanu, J Vinberg, M Assentoft, E Randers, L Harmer, C Ehrenreich, H Paulson, O Knudsen, G Siebner, H Kessing, L |
| author_sort | Miskowiak, K |
| collection | OXFORD |
| description | <h4>Objective</h4> <p>Erythropoietin (EPO) improves verbal memory and reverses sub-field hippocampal volume loss across depression and bipolar disorder. This study aimed to investigate with functional magnetic resonance imaging (fMRI) whether these effects were accompanied by functional changes in memory-relevant neuro-circuits in this cohort. </p> <h4>Method</h4> <p>Eighty-four patients with treatment-resistant unipolar depression who were moderately depressed or bipolar disorder in remission were randomized to eight weekly erythropoietin (40,000 IU) or saline infusions in a double-blind, parallel-group design. Participants underwent whole-brain fMRI at 3T, mood ratings and blood tests at baseline and week 14. During fMRI, participants performed a picture encoding task followed by post-scan recall. </p> <h4>Results</h4> <p>Sixty-two patients had complete data (EPO: N=32, saline: N=30). EPO improved picture recall and increased encoding-related activity in dorsolateral prefrontal cortex (dlPFC) and temporo-parietal regions, but not in hippocampus. Recall correlated with activity in the identified dlPFC and temporo-parietal regions at baseline, and change in recall correlated with activity change in these regions from baseline to follow-up across the entire cohort. The effects of EPO were not correlated with change in mood, red blood cells, blood pressure or medication. </p> <h4>Conclusion</h4> <p>The findings highlight enhanced encoding-related dlPFC and temporo-parietal activity as key neuronal underpinnings of EPO-associated memory improvement. </p> |
| first_indexed | 2024-03-06T19:20:21Z |
| format | Journal article |
| id | oxford-uuid:19e1fcce-b609-4d5c-8069-6ff47dfeb21e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:20:21Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:19e1fcce-b609-4d5c-8069-6ff47dfeb21e2022-03-26T10:51:31ZEffects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:19e1fcce-b609-4d5c-8069-6ff47dfeb21eEnglishSymplectic Elements at OxfordWiley2016Miskowiak, KMacoveanu, JVinberg, MAssentoft, ERanders, LHarmer, CEhrenreich, HPaulson, OKnudsen, GSiebner, HKessing, L <h4>Objective</h4> <p>Erythropoietin (EPO) improves verbal memory and reverses sub-field hippocampal volume loss across depression and bipolar disorder. This study aimed to investigate with functional magnetic resonance imaging (fMRI) whether these effects were accompanied by functional changes in memory-relevant neuro-circuits in this cohort. </p> <h4>Method</h4> <p>Eighty-four patients with treatment-resistant unipolar depression who were moderately depressed or bipolar disorder in remission were randomized to eight weekly erythropoietin (40,000 IU) or saline infusions in a double-blind, parallel-group design. Participants underwent whole-brain fMRI at 3T, mood ratings and blood tests at baseline and week 14. During fMRI, participants performed a picture encoding task followed by post-scan recall. </p> <h4>Results</h4> <p>Sixty-two patients had complete data (EPO: N=32, saline: N=30). EPO improved picture recall and increased encoding-related activity in dorsolateral prefrontal cortex (dlPFC) and temporo-parietal regions, but not in hippocampus. Recall correlated with activity in the identified dlPFC and temporo-parietal regions at baseline, and change in recall correlated with activity change in these regions from baseline to follow-up across the entire cohort. The effects of EPO were not correlated with change in mood, red blood cells, blood pressure or medication. </p> <h4>Conclusion</h4> <p>The findings highlight enhanced encoding-related dlPFC and temporo-parietal activity as key neuronal underpinnings of EPO-associated memory improvement. </p> |
| spellingShingle | Miskowiak, K Macoveanu, J Vinberg, M Assentoft, E Randers, L Harmer, C Ehrenreich, H Paulson, O Knudsen, G Siebner, H Kessing, L Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title | Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title_full | Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title_fullStr | Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title_full_unstemmed | Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title_short | Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. |
| title_sort | effects of erythropoietin on memory relevant neurocircuitry activity and recall in mood disorders |
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