Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attractive because the most mature members neutralize...

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Bibliographic Details
Main Authors: LaBranche, C, Henderson, R, Hsu, A, Behrens, S, Chen, X, Zhou, T, Wiehe, K, Saunders, KO, Alam, SM, Bonsignori, M, Borgnia, MJ, Sattentau, QJ, Eaton, A, Greene, K, Gao, H, Liao, HX, Williams, WB, Peacock, J, Tang, H, Perez, LG, Edwards, RJ, Kepler, TB, Korber, BT, Kwong, PD, Mascola, JR, Acharya, P, Haynes, BF, Montefiori, DC
Format: Journal article
Language:English
Published: Public Library of Science 2019

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