Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

OBJECTIVE: Metformin is actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease the ability of metformin to reduce glucose excursion in response to oral glucose. W...

書誌詳細
主要な著者:	Zhou, K, Donnelly, L, Kimber, C, Donnan, P, Doney, A, Leese, G, Hattersley, A, McCarthy, M, Morris, A, Palmer, C, Pearson, E
フォーマット:	Journal article
言語:	English
出版事項:	2009

類似資料

Metformin Pharmacogenetics and SLC2A2: Genome-Wide Association Study and 2-stage replication in GoDARTS and UKPDS
著者:: Zhou, K, 等
出版事項: (2013)

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
著者:: Pearson, E, 等
出版事項: (2007)

The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response
著者:: Ningrum, Vitarani Dwi Ananda, 等
出版事項: (2022)

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
著者:: Kimber, C, 等
出版事項: (2007)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with Type 2 diabetes: A Go-DARTS study
著者:: Donnelly, L, 等
出版事項: (2011)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
著者:: Donnelly, L, 等
出版事項: (2011)

Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.
著者:: Zhou, K, 等
出版事項: (2010)

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.
著者:: Kahn, SE, 等
出版事項: (2006)

Quantifying the effect of metformin treatment and dose on glycemic control.
著者:: Hirst, J, 等
出版事項: (2012)

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
著者:: Zhou, K, 等
出版事項: (2011)

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
著者:: Zhou, K, 等
出版事項: (2011)

Variation in the glucose transporter gene SLC2A2 is associated with glycaemic response to metformin
著者:: Kaixin, Z, 等
出版事項: (2016)

Risk of anaemia with long-term metformin use in a community setting
著者:: Donnelly, L, 等
出版事項: (2017)

SLC22A1, SLC22A2, SLC22A3 and 11ßHSD1 gene polymorphisms among Malaysian Indians with type 2 diabetes mellitus
著者:: Abood, Al Ashoor Sabah Ghasan
出版事項: (2019)

Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes.
著者:: Cook, M, 等
出版事項: (2005)

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1
著者:: Romero, Rodrigo, 等
出版事項: (2021)

Beyond HbA1c: Comparing Glycemic Variability and Glycemic Indices in Predicting Hypoglycemia in Type 1 and Type 2 Diabetes
著者:: Rama Chandran, Suresh, 等
出版事項: (2018)

MCART1/SLC25A51 is required for mitochondrial NAD transport
著者:: Kory, Nora, 等
出版事項: (2021)

The role of ATM in response to metformin treatment and activation of AMPK.
著者:: Zhou, K, 等
出版事項: (2012)

Structural and functional studies on a prokaryotic homologue of the mammalian SLC7 cationic amino acid transporters
著者:: Jungnickel, K
出版事項: (2018)

SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis
著者:: Dayang Nooreffazleen Yahya, 等
出版事項: (2023)

Depressed mood is a factor in glycemic control in type 1 diabetes.
著者:: Tilburg, V, 等
出版事項: (2001)

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort
著者:: Duell, E, 等
出版事項: (2013)

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
著者:: Duell, E, 等
出版事項: (2013)

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus - Progressive requirement for multiple therapies (UKPDS 49)
著者:: Turner, R, 等
出版事項: (1999)

One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes.
著者:: Hanefeld, M, 等
出版事項: (2004)

DART and laboratory monitoring of HIV treatment Reply
著者:: Walker, A, 等
出版事項: (2010)

A measurement of the tau Michel parameters at SLC
著者:: Quigley, James A
出版事項: (2009)

The sustained influence of metformin therapy on circulating GLP-1 levels in individuals with and without type 2 diabetes
著者:: Preiss, D, 等
出版事項: (2016)

The SLC16 monocaboxylate transporter family.
著者:: Meredith, D, 等
出版事項: (2008)

Expression analysis of COMMD5, NPPA, SLC7A1 and AT1R genes among hypertensive Malays
著者:: Bdair, Ban Waheed Hussein
出版事項: (2017)

Interdependent transcription of a natural sense/antisense transcripts pair (SLC34A1/PFN3)
著者:: Zinad, H, 等
出版事項: (2022)

Quantification of AMY1 gene copy number and its association with glycemic response.
著者:: Lee, Jin Shun.
出版事項: (2013)

Pioglitazone and metformin.
著者:: Hill, N, 等
出版事項: (2007)

Pharmacogenetics in Type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas
著者:: Pearson, E, 等
出版事項: (2007)

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
著者:: Lopez-Serra, Paula, 等
出版事項: (2015)

Penanggulangan anemia defisiens1 besi dengan cara suplementasi besi: Suatu pendekatan dart segi ORSA
著者:: Perpustakaan UGM, i-lib
出版事項: (1992)

ADGRL4/ELTD1 silencing in endothelial cells induces ACLY and SLC25A1 and alters the cellular metabolic profile
著者:: Favara, DM, 等
出版事項: (2019)

Presynaptic congenital myasthenic syndrome due to three novel mutations in SLC5A7 encoding the sodium-dependant high-affinity choline transporter
著者:: Rodríguez Cruz, PM, 等
出版事項: (2020)

Penggunaan Enzim Protease Non Kolagen Dart Pankreas,
著者:: Perpustakaan UGM, i-lib
出版事項: (1994)