Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
OBJECTIVE: Metformin is actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease the ability of metformin to reduce glucose excursion in response to oral glucose. W...
Main Authors: | Zhou, K, Donnelly, L, Kimber, C, Donnan, P, Doney, A, Leese, G, Hattersley, A, McCarthy, M, Morris, A, Palmer, C, Pearson, E |
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Format: | Journal article |
Language: | English |
Published: |
2009
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