Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labell...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826261463847665664 |
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| author | Rundle, A Richie, J Steindorf, K Peluso, M Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M Barricarte, A Tormo, M Quiros, J Agudo, A Berglund, G |
| author_facet | Rundle, A Richie, J Steindorf, K Peluso, M Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M Barricarte, A Tormo, M Quiros, J Agudo, A Berglund, G |
| author_sort | Rundle, A |
| collection | OXFORD |
| description | The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. |
| first_indexed | 2024-03-06T19:21:51Z |
| format | Journal article |
| id | oxford-uuid:1a5e1d55-2a0d-4984-87f1-d13310b56e91 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:21:51Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:1a5e1d55-2a0d-4984-87f1-d13310b56e912022-03-26T10:54:26ZPhysical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1a5e1d55-2a0d-4984-87f1-d13310b56e91EnglishSymplectic Elements at Oxford2010Rundle, ARichie, JSteindorf, KPeluso, MOvervad, KRaaschou-Nielsen, OClavel-Chapelon, FLinseisen, JBoeing, HTrichopoulou, APalli, DKrogh, VTumino, RPanico, SBueno-De-Mesquita, HPeeters, PLund, EGonzalez, CMartinez, CDorronsoro, MBarricarte, ATormo, MQuiros, JAgudo, ABerglund, GThe association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. |
| spellingShingle | Rundle, A Richie, J Steindorf, K Peluso, M Overvad, K Raaschou-Nielsen, O Clavel-Chapelon, F Linseisen, J Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R Panico, S Bueno-De-Mesquita, H Peeters, P Lund, E Gonzalez, C Martinez, C Dorronsoro, M Barricarte, A Tormo, M Quiros, J Agudo, A Berglund, G Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title | Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title_full | Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title_fullStr | Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title_full_unstemmed | Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title_short | Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. |
| title_sort | physical activity and lung cancer among non smokers a pilot molecular epidemiological study within epic |
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