High-resolution mass spectrometry of small molecules bound to membrane proteins

Small molecules are known to stabilize membrane proteins and to modulate their function and oligomeric state, but such interactions are often hard to precisely define. Here we develop and apply a high-resolution, Orbitrap mass spectrometry–based method for analyzing intact membrane protein–ligand co...

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Bibliographic Details
Main Authors: Gault, J, Donlan, J, Liko, I, Hopper, J, Gupta, K, Housden, N, Struwe, W, Marty, M, Mize, T, Bechara, C, Zhu, Y, Wu, B, Kleanthous, C, Belov, M, Damoc, E, Makarov, A, Robinson, C
Format: Journal article
Language:English
Published: Springer Nature 2016

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