Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.

Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.

Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobulin superfamily domains, by x-ray crystallography t...

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Bibliographic Details
Main Authors:	Hatherley, D, Graham, S, Harlos, K, Stuart, D, Barclay, N
Format:	Journal article
Language:	English
Published:	2009

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