Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

BACKGROUND: Pyronaridine-artesunate is an artemisinin-based combination therapy under evaluation for the treatment of Plasmodium falciparum and P. vivax malaria. METHODS: We conducted a phase 3, open-label, multicenter, noninferiority trial that included 1271 patients between 3 and 60 years of age f...

Full description

Bibliographic Details
Main Authors:	Rueangweerayut, R, Phyo, A, Uthaisin, C, Poravuth, Y, Binh, T, Tinto, H, Pénali, L, Valecha, N, Tien, N, Abdulla, S, Borghini-Fuhrer, I, Duparc, S, Shin, C, Fleckenstein, L
Format:	Journal article
Language:	English
Published:	Massachusetts Medical Society 2012

Similar Items

Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial
by: Poravuth, Y, et al.
Published: (2011)

Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial.
by: Yi Poravuth, et al.
Published: (2011-01-01)

Pyronaridine-artesunate for uncomplicated falciparum malaria.
by: Nosten, F
Published: (2010)

Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with <it>Plasmodium falciparum</it> malaria: a randomized controlled trial
by: Kayentao Kassoum, et al.
Published: (2012-10-01)

Safety and efficacy of pyronaridine–artesunate paediatric granules in the treatment of uncomplicated malaria in children: insights from randomized clinical trials and a real-world study
by: Michael Ramharter, et al.
Published: (2024-02-01)

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia
by: Valecha, N, et al.
Published: (2010)

Simultaneous Spectrophotometric Estimation of Artesunate and Mefloquine
by: T. M. Kalyankar, et al.
Published: (2013-01-01)

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
by: Valecha, N, et al.
Published: (2010)

Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria.
by: Price, R, et al.
Published: (1997)

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
by: Neena Valecha, et al.
Published: (2010-01-01)

Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.
by: Jittamala, P, et al.
Published: (2015)

Correction: An Open-Label, Randomised Study of Dihydroartemisinin-Piperaquine Versus Artesunate-Mefloquine for Falciparum Malaria in Asia.
by: Neena Valecha, et al.
Published: (2010-01-01)

Correction: An Open-Label, Randomised Study of Dihydroartemisinin-Piperaquine Versus Artesunate-Mefloquine for Falciparum Malaria in Asia.
by: Neena Valecha, et al.
Published: (2010-01-01)

Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.
by: Price, R, et al.
Published: (1999)

Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated <it>Plasmodium falciparum </it>malaria
by: Quezada Wilmer, et al.
Published: (2009-04-01)

Plasmodium falciparum gametocyte dynamics after pyronaridine–artesunate or artemether–lumefantrine treatment
by: Johanna M. Roth, et al.
Published: (2018-06-01)

The neurological assessment in young children treated with artesunate monotherapy or artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria.
by: Ambler, M, et al.
Published: (2009)

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
by: Shin Chang-Sik, et al.
Published: (2011-09-01)

Artesunate and mefloquine in the treatment of uncomplicated multidrug-resistant hyperparasitaemic falciparum malaria.
by: Price, R, et al.
Published: (1998)

Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria.
by: Price, R, et al.
Published: (1995)

The neurological assessment in young children treated with artesunate monotherapy or artesunate-mefloquine combination therapy for uncomplicated <it>Plasmodium falciparum </it>malaria
by: Singhasivanon Pratap, et al.
Published: (2009-09-01)

Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria.
by: Luxemburger, C, et al.
Published: (1994)

Review of pyronaridine anti-malarial properties and product characteristics
by: Croft Simon L, et al.
Published: (2012-08-01)

Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar.
by: Smithuis, F, et al.
Published: (2004)

Resistance to Artesunate + Mefloquine does not incurin fitness cost in malaria parasites
by: Cravo Pedro, et al.
Published: (2010-10-01)

Successful Treatment of Imported Cerebral Malaria with Artesunate-Mefloquine Combination Therapy
by: Hsin-Yun Sun
Published: (2006-01-01)

Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination.
by: Nosten, F, et al.
Published: (1994)

Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
by: Teerachat Saeheng, et al.
Published: (2023-01-01)

Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria.
by: Teerachat Saeheng, et al.
Published: (2023-01-01)

Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of <it>Plasmodium falciparum </it>gametocytes in malarious children
by: Happi Christian T, et al.
Published: (2009-12-01)

Efficacy and safety of pyronaridine-artesunate (Pyramax®) for the treatment of uncomplicated Plasmodium vivax malaria in Northwest Ethiopia
by: Hussein Mohammed, et al.
Published: (2022-12-01)

Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria.
by: van Vugt, M, et al.
Published: (1998)

Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study.
by: Nosten, F, et al.
Published: (2000)

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial.
by: Jennifer Keiser, et al.
Published: (2014-07-01)

Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated <it>Plasmodium falciparum</it> malaria in India
by: Gargano Nicola, et al.
Published: (2012-07-01)

Optimising operational use of artesunate-mefloquine: a randomised comparison of four treatment regimens.
by: Smithuis, F, et al.
Published: (2004)

In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003.
by: Ashley, E, et al.
Published: (2006)

Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.
by: Gaston Tona Lutete, et al.
Published: (2021-06-01)

Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters
by: Dong Wook Kang, et al.
Published: (2023-03-01)

Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
by: Carrara, V, et al.
Published: (2009)