A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.
Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneo...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
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2007
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author | Ferguson, S Brasnjo, G Hayashi, M Wölfel, M Collesi, C Giovedi, S Raimondi, A Gong, L Ariel, P Paradise, S O'toole, E Flavell, R Cremona, O Miesenböck, G Ryan, T De Camilli, P |
author_facet | Ferguson, S Brasnjo, G Hayashi, M Wölfel, M Collesi, C Giovedi, S Raimondi, A Gong, L Ariel, P Paradise, S O'toole, E Flavell, R Cremona, O Miesenböck, G Ryan, T De Camilli, P |
author_sort | Ferguson, S |
collection | OXFORD |
description | Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity. |
first_indexed | 2024-03-06T19:22:36Z |
format | Journal article |
id | oxford-uuid:1a9b3bf2-15a5-49a0-9c5c-78f8527a3f44 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T19:22:36Z |
publishDate | 2007 |
record_format | dspace |
spelling | oxford-uuid:1a9b3bf2-15a5-49a0-9c5c-78f8527a3f442022-03-26T10:55:52ZA selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1a9b3bf2-15a5-49a0-9c5c-78f8527a3f44EnglishSymplectic Elements at Oxford2007Ferguson, SBrasnjo, GHayashi, MWölfel, MCollesi, CGiovedi, SRaimondi, AGong, LAriel, PParadise, SO'toole, EFlavell, RCremona, OMiesenböck, GRyan, TDe Camilli, PDynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity. |
spellingShingle | Ferguson, S Brasnjo, G Hayashi, M Wölfel, M Collesi, C Giovedi, S Raimondi, A Gong, L Ariel, P Paradise, S O'toole, E Flavell, R Cremona, O Miesenböck, G Ryan, T De Camilli, P A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title | A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title_full | A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title_fullStr | A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title_full_unstemmed | A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title_short | A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. |
title_sort | selective activity dependent requirement for dynamin 1 in synaptic vesicle endocytosis |
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