Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
The 2014-15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against out...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Taylor and Francis
2017
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| _version_ | 1797056380088090624 |
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| author | Ewer (nee Russell), K Sebastian, S Spencer, A Gilbert, S Hill, A Lambe, T |
| author_facet | Ewer (nee Russell), K Sebastian, S Spencer, A Gilbert, S Hill, A Lambe, T |
| author_sort | Ewer (nee Russell), K |
| collection | OXFORD |
| description | The 2014-15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS. |
| first_indexed | 2024-03-06T19:22:36Z |
| format | Journal article |
| id | oxford-uuid:1a9d62f3-5d24-4feb-bd87-973a2143baa5 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:22:36Z |
| publishDate | 2017 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:1a9d62f3-5d24-4feb-bd87-973a2143baa52022-03-26T10:55:48ZChimpanzee adenoviral vectors as vaccines for outbreak pathogensJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1a9d62f3-5d24-4feb-bd87-973a2143baa5Symplectic Elements at OxfordTaylor and Francis2017Ewer (nee Russell), KSebastian, SSpencer, AGilbert, SHill, ALambe, TThe 2014-15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS. |
| spellingShingle | Ewer (nee Russell), K Sebastian, S Spencer, A Gilbert, S Hill, A Lambe, T Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title | Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title_full | Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title_fullStr | Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title_full_unstemmed | Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title_short | Chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| title_sort | chimpanzee adenoviral vectors as vaccines for outbreak pathogens |
| work_keys_str_mv | AT ewerneerussellk chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens AT sebastians chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens AT spencera chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens AT gilberts chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens AT hilla chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens AT lambet chimpanzeeadenoviralvectorsasvaccinesforoutbreakpathogens |