The antigenic anatomy of SARS-CoV-2 receptor binding domain

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD). We devise a competition data-driven met...

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Main Authors: Dejnirattisai, W, Zhou, D, Ginn, HM, Duyvesteyn, HME, Spasa, D, Case, JB, Zhao, Y, Walter, TS, Mentzer, AJ, Liu, C, Wang, B, Paesen, GC, Slon-Campus, J, López-Camacho, C, Kafai, NM, Bailey, AL, Chen, RE, Ying, B, Thompson, C, Bolton, J, Fyfe, A, Gupta, S, Tan, TK, Gilbert-Jaramillo, J, James, W, Knight, M, Carroll, MW, Skelly, D, Dold, C, Peng, Y, Levin, R, Dong, T, Pollard, AJ, Knight, JC, Klenerman, P, Temperton, N, Hall, DR, Williams, MA, Paterson, NG, Bertram, FKR, Seibert, CA, Clare, DK, Howe, A, Raedecke, J, Song, Y, Townsend, AR, Huang, K-YA, Fry, EE, Mongkolsapaya, J, Diamond, MS, Ren, J, Stuart, DI, Screaton, GR
Format: Journal article
Language:English
Published: Cell Press 2021

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