Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy
Magnetic resonance spectroscopy (MRS) is a versatile and powerful tool for the non invasive study of cardiac metabolism and can be used to measure myocardial concentrations of many different metabolites. The most widely studied nucleus, phosphorus-31, allows for the detection of phosphocreatine, ATP...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797056405818048512 |
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| author | Ten Hove, M Neubauer, S |
| author_facet | Ten Hove, M Neubauer, S |
| author_sort | Ten Hove, M |
| collection | OXFORD |
| description | Magnetic resonance spectroscopy (MRS) is a versatile and powerful tool for the non invasive study of cardiac metabolism and can be used to measure myocardial concentrations of many different metabolites. The most widely studied nucleus, phosphorus-31, allows for the detection of phosphocreatine, ATP, intracellular pH, and flux through the creatine kinase reaction. Carbon-13-MRS has a low sensitivity, but several metabolites can be measured to facilitate study of substrate utilization and flux. Finally, hydrogen-1 (proton)-MRS can be used to study myocardial oxygenation and creatine concentrations. Here, we give a brief overview of the different applications of cardiac MRS and the pathophysiological insights derived from such studies. |
| first_indexed | 2024-03-06T19:22:45Z |
| format | Journal article |
| id | oxford-uuid:1aa7022e-6deb-4cbf-a994-a7bb484155f7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:22:45Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:1aa7022e-6deb-4cbf-a994-a7bb484155f72022-03-26T10:56:05ZEvaluating metabolic changes in heart disease by magnetic resonance spectroscopyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1aa7022e-6deb-4cbf-a994-a7bb484155f7EnglishSymplectic Elements at Oxford2006Ten Hove, MNeubauer, SMagnetic resonance spectroscopy (MRS) is a versatile and powerful tool for the non invasive study of cardiac metabolism and can be used to measure myocardial concentrations of many different metabolites. The most widely studied nucleus, phosphorus-31, allows for the detection of phosphocreatine, ATP, intracellular pH, and flux through the creatine kinase reaction. Carbon-13-MRS has a low sensitivity, but several metabolites can be measured to facilitate study of substrate utilization and flux. Finally, hydrogen-1 (proton)-MRS can be used to study myocardial oxygenation and creatine concentrations. Here, we give a brief overview of the different applications of cardiac MRS and the pathophysiological insights derived from such studies. |
| spellingShingle | Ten Hove, M Neubauer, S Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title | Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title_full | Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title_fullStr | Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title_full_unstemmed | Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title_short | Evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| title_sort | evaluating metabolic changes in heart disease by magnetic resonance spectroscopy |
| work_keys_str_mv | AT tenhovem evaluatingmetabolicchangesinheartdiseasebymagneticresonancespectroscopy AT neubauers evaluatingmetabolicchangesinheartdiseasebymagneticresonancespectroscopy |