Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

Human induced pluripotent stem cells (hiPSCs) have become indispensable for disease modelling. They are an important resource to access patient cells harbouring disease-causing mutations. Derivation of midbrain dopaminergic (DAergic) neurons from hiPSCs of PD patients represents the only option to m...

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Hlavní autoři: Überbacher, C, Obergasteiger, J, Volta, M, Venezia, S, Müller, S, Pesce, I, Pizzi, S, Lamonaca, G, Picard, A, Cattelan, G, Malpeli, G, Zoli, M, Beccano-Kelly, D, Flynn, R, Wade-Martins, R, Pramstaller, P, Hicks, A, Cowley, S, Corti, C
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2019

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