Burrowing into prion disease.
Mice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797056485199446016 |
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| author | Deacon, R Raley, J Perry, V Rawlins, J |
| author_facet | Deacon, R Raley, J Perry, V Rawlins, J |
| author_sort | Deacon, R |
| collection | OXFORD |
| description | Mice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics. |
| first_indexed | 2024-03-06T19:23:24Z |
| format | Journal article |
| id | oxford-uuid:1ae3e097-641f-4413-b376-cd3a11690b5e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:23:24Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:1ae3e097-641f-4413-b376-cd3a11690b5e2022-03-26T10:57:18ZBurrowing into prion disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1ae3e097-641f-4413-b376-cd3a11690b5eEnglishSymplectic Elements at Oxford2001Deacon, RRaley, JPerry, VRawlins, JMice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics. |
| spellingShingle | Deacon, R Raley, J Perry, V Rawlins, J Burrowing into prion disease. |
| title | Burrowing into prion disease. |
| title_full | Burrowing into prion disease. |
| title_fullStr | Burrowing into prion disease. |
| title_full_unstemmed | Burrowing into prion disease. |
| title_short | Burrowing into prion disease. |
| title_sort | burrowing into prion disease |
| work_keys_str_mv | AT deaconr burrowingintopriondisease AT raleyj burrowingintopriondisease AT perryv burrowingintopriondisease AT rawlinsj burrowingintopriondisease |