Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom.
There is uncertainty about the importance of plasma levels of homocysteine, vitamin B-12, and folate for all-cause and cardiovascular disease (CVD) mortality in older people. We examined the associations between plasma levels of folate, vitamin B-12, and homocysteine, and all-cause and CVD mortality...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797056523384389632 |
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| author | Dangour, A Breeze, E Clarke, R Shetty, P Uauy, R Fletcher, A |
| author_facet | Dangour, A Breeze, E Clarke, R Shetty, P Uauy, R Fletcher, A |
| author_sort | Dangour, A |
| collection | OXFORD |
| description | There is uncertainty about the importance of plasma levels of homocysteine, vitamin B-12, and folate for all-cause and cardiovascular disease (CVD) mortality in older people. We examined the associations between plasma levels of folate, vitamin B-12, and homocysteine, and all-cause and CVD mortality among community-dwelling adults aged > or = 75 y living in the United Kingdom. In a population-based prospective cohort study, 853 men and women aged > or = 75 y were examined in 1995-98 as part of the Medical Research Council Trial of Assessment and Management of Older People in the Community. During a median follow-up of 7.6 y (5528 person-years of follow-up), 429 individuals (50.3%) died, including 185 from CVD. Individuals with plasma homocysteine levels in the top one-third compared with the bottom one-third had a 2-fold higher risk of all-cause mortality (hazard ratio, 2.20; 95% CI, 1.76, 2.75; P < 0.001) and CVD mortality (hazard ratio, 1.96; 95% CI, 1.39, 2.78; P < 0.001) after adjustment for age, sex, and other covariates. There was no association of plasma folate or vitamin B-12 levels with mortality. Our results extend previously reported associations of homocysteine with mortality, and the absence of associations of folate and vitamin B-12 with mortality, to the older population. |
| first_indexed | 2024-03-06T19:23:53Z |
| format | Journal article |
| id | oxford-uuid:1b0ebc79-c44a-4975-a7d9-3eb646ebb088 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:23:53Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:1b0ebc79-c44a-4975-a7d9-3eb646ebb0882022-03-26T10:58:10ZPlasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1b0ebc79-c44a-4975-a7d9-3eb646ebb088EnglishSymplectic Elements at Oxford2008Dangour, ABreeze, EClarke, RShetty, PUauy, RFletcher, AThere is uncertainty about the importance of plasma levels of homocysteine, vitamin B-12, and folate for all-cause and cardiovascular disease (CVD) mortality in older people. We examined the associations between plasma levels of folate, vitamin B-12, and homocysteine, and all-cause and CVD mortality among community-dwelling adults aged > or = 75 y living in the United Kingdom. In a population-based prospective cohort study, 853 men and women aged > or = 75 y were examined in 1995-98 as part of the Medical Research Council Trial of Assessment and Management of Older People in the Community. During a median follow-up of 7.6 y (5528 person-years of follow-up), 429 individuals (50.3%) died, including 185 from CVD. Individuals with plasma homocysteine levels in the top one-third compared with the bottom one-third had a 2-fold higher risk of all-cause mortality (hazard ratio, 2.20; 95% CI, 1.76, 2.75; P < 0.001) and CVD mortality (hazard ratio, 1.96; 95% CI, 1.39, 2.78; P < 0.001) after adjustment for age, sex, and other covariates. There was no association of plasma folate or vitamin B-12 levels with mortality. Our results extend previously reported associations of homocysteine with mortality, and the absence of associations of folate and vitamin B-12 with mortality, to the older population. |
| spellingShingle | Dangour, A Breeze, E Clarke, R Shetty, P Uauy, R Fletcher, A Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title | Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title_full | Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title_fullStr | Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title_full_unstemmed | Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title_short | Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom. |
| title_sort | plasma homocysteine but not folate or vitamin b 12 predicts mortality in older people in the united kingdom |
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