The role of mucosal T lymphocytes in regulating intestinal inflammation.
Suppression of chronic intestinal inflammation by different subtypes of T cells has been described in recent years. In particular, naturally arising CD4(+)CD25(+) regulatory T cells and IL-10-producing regulatory T cell type 1 CD4(+) T lymphocytes have been implicated in the regulation of intestinal...
| المؤلفون الرئيسيون: | , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2005
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| _version_ | 1826261606204440576 |
|---|---|
| author | Uhlig, H Powrie, F |
| author_facet | Uhlig, H Powrie, F |
| author_sort | Uhlig, H |
| collection | OXFORD |
| description | Suppression of chronic intestinal inflammation by different subtypes of T cells has been described in recent years. In particular, naturally arising CD4(+)CD25(+) regulatory T cells and IL-10-producing regulatory T cell type 1 CD4(+) T lymphocytes have been implicated in the regulation of intestinal inflammation. Here we focus on the ability of CD4(+)CD25(+) regulatory T cells to suppress innate and T-cell responses and discuss implications for immunoregulation in human inflammatory bowel disease. Besides the modulation of lymphoproliferation, a role for CD4(+)CD25(+) T cells in down-modulation of innate immune responses is emerging and the immunoregulatory activities of regulatory T cells in vivo may be mediated via effects on dendritic cells. Considering the extraordinary regenerative potential of the intestinal mucosa, the ability to impede pathogenic T-cell responses by active regulation might be of particular therapeutic benefit for the treatment of chronic intestinal inflammatory diseases such as Crohn's disease and ulcerative colitis. |
| first_indexed | 2024-03-06T19:24:02Z |
| format | Journal article |
| id | oxford-uuid:1b1a84f1-8f97-4883-8bad-c36349a3fbeb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:24:02Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:1b1a84f1-8f97-4883-8bad-c36349a3fbeb2022-03-26T10:58:27ZThe role of mucosal T lymphocytes in regulating intestinal inflammation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1b1a84f1-8f97-4883-8bad-c36349a3fbebEnglishSymplectic Elements at Oxford2005Uhlig, HPowrie, FSuppression of chronic intestinal inflammation by different subtypes of T cells has been described in recent years. In particular, naturally arising CD4(+)CD25(+) regulatory T cells and IL-10-producing regulatory T cell type 1 CD4(+) T lymphocytes have been implicated in the regulation of intestinal inflammation. Here we focus on the ability of CD4(+)CD25(+) regulatory T cells to suppress innate and T-cell responses and discuss implications for immunoregulation in human inflammatory bowel disease. Besides the modulation of lymphoproliferation, a role for CD4(+)CD25(+) T cells in down-modulation of innate immune responses is emerging and the immunoregulatory activities of regulatory T cells in vivo may be mediated via effects on dendritic cells. Considering the extraordinary regenerative potential of the intestinal mucosa, the ability to impede pathogenic T-cell responses by active regulation might be of particular therapeutic benefit for the treatment of chronic intestinal inflammatory diseases such as Crohn's disease and ulcerative colitis. |
| spellingShingle | Uhlig, H Powrie, F The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title | The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title_full | The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title_fullStr | The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title_full_unstemmed | The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title_short | The role of mucosal T lymphocytes in regulating intestinal inflammation. |
| title_sort | role of mucosal t lymphocytes in regulating intestinal inflammation |
| work_keys_str_mv | AT uhligh theroleofmucosaltlymphocytesinregulatingintestinalinflammation AT powrief theroleofmucosaltlymphocytesinregulatingintestinalinflammation AT uhligh roleofmucosaltlymphocytesinregulatingintestinalinflammation AT powrief roleofmucosaltlymphocytesinregulatingintestinalinflammation |