Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Nitric oxide (NO), which is derived from endothelial NO synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an absolute requirement for eNOS activity. In this study, we investigated whether this activation is both maintained by a wil...

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Bibliographic Details
Main Authors:	Chen, L, Zeng, X, Wang, J, Briggs, S, O'Neill, E, Li, J, Leek, R, Kerr, D, Harris, A, Cai, S
Format:	Journal article
Language:	English
Published:	2010

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