TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease with a mean survival time of three years. The 97% of the cases have TDP-43 nuclear depletion and cytoplasmic aggregation in motor neurons. TDP-43 prevents non-conserved cryptic exon splicing in certain genes, maintaining tran...

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書誌詳細
主要な著者: Torres, P, Rico-Rios, S, Ceron-Codorniu, M, Santacreu-Vilaseca, M, Seoane-Miraz, D, Jad, Y, Ayala, V, Mariño, G, Beltran, M, Miralles, MP, Andrés-Benito, P, Fernandez-Irigoyen, J, Santamaria, E, López-Otín, C, Soler, RM, Povedano, M, Ferrer, I, Pamplona, R, Wood, MJA, Varela, MA, Portero-Otin, M
フォーマット: Journal article
言語:English
出版事項: Springer 2024

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