Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality

Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality

Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, drug resistance is a clinical hurdle, and we poorly understand how cancer cells escape the deadly effec...

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المؤلفون الرئيسيون: Gogola, E, Duarte, AA, de Ruiter, JR, Wiegant, WW, Schmid, JA, de Bruijn, R, James, DI, Llobet, SG, Vis, DJ, Annunziato, S, van den Broek, B, Barazas, M, Kersbergen, A, van de Ven, M, Tarsounas, M, Ogilvie, DJ, van Vugt, M, Wessels, LFA, Bartkova, J, Gromova, I, Andújar-Sánchez, M, Bartek, J, Lopes, M, van Attikum, H, Borst, P, Jonkers, J, Rottenberg, S
التنسيق: Journal article
اللغة:English
منشور في: Cell Press 2018

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