11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess.

11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess.

The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess, Cushing syndrome, create a significant health burden. We found that tissue regeneration of GCs by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), rather than circulating delivery, is critical to developing the...

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Bibliographic Details
Main Authors:	Morgan, SA, McCabe, E, Gathercole, L, Hassan-Smith, Z, Larner, D, Bujalska, I, Stewart, P, Tomlinson, J, Lavery, G
Format:	Journal article
Language:	English
Published:	National Academy of Sciences 2014

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