Multi-scale interaction of particulate flow and the artery wall.
We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall e...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1826261692104835072 |
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| author | Halliday, I Atherton, M Care, C Collins, M Evans, D Evans, P Hose, DR Khir, A König, C Krams, R Lawford, P Lishchuk, S Pontrelli, G Ridger, V Spencer, T Ventikos, Y Walker, D Watton, P |
| author_facet | Halliday, I Atherton, M Care, C Collins, M Evans, D Evans, P Hose, DR Khir, A König, C Krams, R Lawford, P Lishchuk, S Pontrelli, G Ridger, V Spencer, T Ventikos, Y Walker, D Watton, P |
| author_sort | Halliday, I |
| collection | OXFORD |
| description | We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state. |
| first_indexed | 2024-03-06T19:25:20Z |
| format | Journal article |
| id | oxford-uuid:1b819680-cf89-4543-9c7a-8c863dbe2200 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:25:20Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:1b819680-cf89-4543-9c7a-8c863dbe22002022-03-26T11:00:46ZMulti-scale interaction of particulate flow and the artery wall.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1b819680-cf89-4543-9c7a-8c863dbe2200EnglishSymplectic Elements at Oxford2011Halliday, IAtherton, MCare, CCollins, MEvans, DEvans, PHose, DRKhir, AKönig, CKrams, RLawford, PLishchuk, SPontrelli, GRidger, VSpencer, TVentikos, YWalker, DWatton, PWe discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state. |
| spellingShingle | Halliday, I Atherton, M Care, C Collins, M Evans, D Evans, P Hose, DR Khir, A König, C Krams, R Lawford, P Lishchuk, S Pontrelli, G Ridger, V Spencer, T Ventikos, Y Walker, D Watton, P Multi-scale interaction of particulate flow and the artery wall. |
| title | Multi-scale interaction of particulate flow and the artery wall. |
| title_full | Multi-scale interaction of particulate flow and the artery wall. |
| title_fullStr | Multi-scale interaction of particulate flow and the artery wall. |
| title_full_unstemmed | Multi-scale interaction of particulate flow and the artery wall. |
| title_short | Multi-scale interaction of particulate flow and the artery wall. |
| title_sort | multi scale interaction of particulate flow and the artery wall |
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