Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
BACKGROUND: Although dietary folate fortification lowers plasma homocysteine and may reduce cardiovascular risk, high-dose folic acid therapy appears to not alter clinical outcome. Folic acid and its principal circulating metabolite, 5-methyltetrahydrofolate, improve vascular function, but mechanism...
Main Authors: | Shirodaria, C, Antoniades, C, Lee, J, Jackson, C, Robson, M, Francis, J, Moat, S, Ratnatunga, C, Pillai, R, Refsum, H, Neubauer, S, Channon, K |
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Format: | Journal article |
Language: | English |
Published: |
2007
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